Nuclear pore complex protein Nup205 (NUP205) is a 2012-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q92621.
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The mean pLDDT of this model is 78.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 20% |
| 70 to 90 | Confident: backbone generally right | 60% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC (PubMed:15229283). In association with TMEM209, may be involved in nuclear transport of various nuclear proteins in addition to MYC (PubMed:22719065)
Part of the nuclear pore complex (NPC) (PubMed:15229283, PubMed:9348540). Forms a complex with NUP35, NUP93, NUP155 and lamin B (PubMed:15703211, PubMed:26878725). Does not interact with TPR (PubMed:12802065). Interacts with TMEM209 and MYC (PubMed:18691976)
Nucleus membrane, Nucleus, nuclear pore complex
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7R5K | EM | 12.0 Å | C0/C1/C2/C3/C4=1-2012 |
| 5IJN | EM | 21.4 Å | D/J/P/V=1-2012 |
| 5IJO | EM | 21.4 Å | D/P=1-2012 |
| 7PER | EM | 35.0 Å | D/J/P/V=1-2012 |
| 7R5J | EM | 50.0 Å | C0/C1/C2/C3/C4=1-2012 |
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