5IJO: Nuclear pore complex protein Nup155
Alternative composite structure of the inner ring of the human nuclear pore complex (16 copies of Nup188, 16 copies of Nup205). Determined by electron microscopy at 21.4 Å resolution. Released 27 Apr 2016.
- Method
- Electron microscopy
- Resolution
- 21.4 Å
- Organism
- Homo sapiens
- Chains
- 26
- Atoms
- 76,526
- Mol. weight
- 2834.29 kDa
- Released
- 27 Apr 2016
Explore 5IJO in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
5IJO contains 754 α-helices and 311 β-strands across 26 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chains A and B: 21 helices, 38 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 22-39 | 18 | |
| α-helix | 46-49 | 4 | |
| β-strand | 63-64 | 2 | 1 |
| β-strand | 81-88 | 8 | 2 |
| α-helix | 89-90 | 2 | |
| α-helix | 91-95 | 5 | |
| β-strand | 104-109 | 6 | 3 |
| β-strand | 114-119 | 6 | 3 |
| β-strand | 122-127 | 6 | 3 |
| β-strand | 134-137 | 4 | 3 |
| β-strand | 146-150 | 5 | 4 |
| α-helix | 151-153 | 3 | |
| β-strand | 163-168 | 6 | 4 |
| β-strand | 172-180 | 9 | 4 |
| β-strand | 198-202 | 5 | 4 |
| β-strand | 208-209 | 2 | 4 |
| β-strand | 215-220 | 6 | 5 |
| β-strand | 226-230 | 5 | 5 |
| β-strand | 236-238 | 3 | 5 |
| β-strand | 255-256 | 2 | 5 |
| β-strand | 279-285 | 7 | 6 |
| β-strand | 290-295 | 6 | 6 |
| β-strand | 300-306 | 7 | 6 |
| β-strand | 309-311 | 3 | 6 |
| β-strand | 317-318 | 2 | 6 |
| α-helix | 320-327 | 8 | |
| β-strand | 344-347 | 4 | 7 |
| β-strand | 356-361 | 6 | 7 |
| β-strand | 367-371 | 5 | 7 |
| β-strand | 375 | 1 | 8 |
| β-strand | 381 | 1 | 8 |
| β-strand | 386-391 | 6 | 7 |
| β-strand | 406 | 1 | 1 |
| β-strand | 411-413 | 3 | 1 |
| β-strand | 417-423 | 7 | 1 |
| β-strand | 429-436 | 8 | 1 |
| β-strand | 447-452 | 6 | 1 |
| β-strand | 460-463 | 4 | 2 |
| α-helix | 496-498 | 3 | |
| β-strand | 499-503 | 5 | 2 |
| β-strand | 507-513 | 7 | 2 |
| α-helix | 514-515 | 2 | |
| α-helix | 516-522 | 7 | |
| α-helix | 536-542 | 7 | |
| α-helix | 544-556 | 13 | |
| α-helix | 564-576 | 13 | |
| α-helix | 661-679 | 19 | |
| β-strand | 681 | 1 | 9 |
| β-strand | 683 | 1 | 10 |
| β-strand | 700 | 1 | 10 |
| α-helix | 704-723 | 20 | |
| α-helix | 725-728 | 4 | |
| α-helix | 770-800 | 31 | |
| α-helix | 803-810 | 8 | |
| α-helix | 815-819 | 5 | |
| β-strand | 822 | 1 | 9 |
| α-helix | 823-827 | 5 | |
| α-helix | 831-843 | 13 | |
| α-helix | 850-862 | 13 | |
Chain C: 37 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-16 | 12 | |
| α-helix | 33-41 | 9 | |
| α-helix | 177-198 | 22 | |
| α-helix | 204-212 | 9 | |
| α-helix | 220-229 | 10 | |
| α-helix | 254-274 | 21 | |
| α-helix | 289-299 | 11 | |
| β-strand | 312-313 | 2 | 21 |
| β-strand | 316-317 | 2 | 21 |
| α-helix | 318-328 | 11 | |
| α-helix | 331-340 | 10 | |
| α-helix | 347-352 | 6 | |
| α-helix | 369-374 | 6 | |
| α-helix | 375-379 | 5 | |
| α-helix | 385-395 | 11 | |
| α-helix | 410-420 | 11 | |
| α-helix | 437-446 | 10 | |
| α-helix | 449-452 | 4 | |
| α-helix | 462-469 | 8 | |
| α-helix | 472-479 | 8 | |
| α-helix | 486-498 | 13 | |
| α-helix | 528-539 | 12 | |
| α-helix | 544-552 | 9 | |
| α-helix | 553-556 | 4 | |
| α-helix | 562-577 | 16 | |
| α-helix | 580-584 | 5 | |
| β-strand | 585-586 | 2 | 22 |
| α-helix | 593 | 1 | |
| β-strand | 594-595 | 2 | 22 |
| α-helix | 597-601 | 5 | |
| α-helix | 606-619 | 14 | |
| α-helix | 624-632 | 9 | |
| α-helix | 635-646 | 12 | |
| α-helix | 663-675 | 13 | |
| β-strand | 679 | 1 | 24 |
| α-helix | 683-701 | 19 | |
| α-helix | 707-717 | 11 | |
| α-helix | 729-735 | 7 | |
| α-helix | 739-759 | 21 | |
| α-helix | 761-763 | 3 | |
| α-helix | 787-798 | 12 | |
| α-helix | 809-813 | 5 | |
Chains D and P: 64 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 15-23 | 9 | |
| α-helix | 41-45 | 5 | |
| α-helix | 47-51 | 5 | |
| α-helix | 62-68 | 7 | |
| β-strand | 71-72 | 2 | 25 |
| β-strand | 84-85 | 2 | 25 |
| α-helix | 88-101 | 14 | |
| α-helix | 105-114 | 10 | |
| α-helix | 130-152 | 23 | |
| α-helix | 165-172 | 8 | |
| α-helix | 182-193 | 12 | |
| α-helix | 197-205 | 9 | |
| α-helix | 211-237 | 27 | |
| α-helix | 243-254 | 12 | |
| α-helix | 268-280 | 13 | |
| α-helix | 305-316 | 12 | |
| α-helix | 317-319 | 3 | |
| α-helix | 324-340 | 17 | |
| α-helix | 344-349 | 6 | |
| α-helix | 352 | 1 | |
| α-helix | 353-357 | 5 | |
| α-helix | 358-365 | 8 | |
| α-helix | 368-377 | 10 | |
| α-helix | 385-402 | 18 | |
| α-helix | 404-417 | 14 | |
| α-helix | 430-435 | 6 | |
| α-helix | 438-450 | 13 | |
| α-helix | 461-464 | 4 | |
| α-helix | 494-503 | 10 | |
| α-helix | 507-520 | 14 | |
| α-helix | 524-535 | 12 | |
| α-helix | 555-572 | 18 | |
| α-helix | 592-609 | 18 | |
| α-helix | 614-619 | 6 | |
| α-helix | 626-635 | 10 | |
| α-helix | 643-653 | 11 | |
| α-helix | 661-669 | 9 | |
| α-helix | 687-697 | 11 | |
| α-helix | 701-715 | 15 | |
| α-helix | 733-742 | 10 | |
| α-helix | 755-774 | 20 | |
| α-helix | 778-782 | 5 | |
| α-helix | 793-798 | 6 | |
| α-helix | 802-810 | 9 | |
| α-helix | 815-824 | 10 | |
| α-helix | 840-862 | 23 | |
| α-helix | 863-867 | 5 | |
| α-helix | 868-869 | 2 | |
| α-helix | 883-886 | 4 | |
| α-helix | 893-904 | 12 | |
| α-helix | 910-923 | 14 | |
| α-helix | 1394-1409 | 16 | |
| α-helix | 1415-1432 | 18 | |
| α-helix | 1438-1448 | 11 | |
| β-strand | 1451 | 1 | 26 |
| α-helix | 1458-1516 | 59 | |
| α-helix | 1517-1521 | 5 | |
| α-helix | 1522-1538 | 17 | |
| α-helix | 1545-1564 | 20 | |
| α-helix | 1567-1575 | 9 | |
| α-helix | 1578-1585 | 8 | |
| α-helix | 1592-1594 | 3 | |
| α-helix | 1610-1632 | 23 | |
| α-helix | 1640-1651 | 12 | |
| α-helix | 1655-1659 | 5 | |
| α-helix | 1665-1683 | 19 | |
| α-helix | 1687-1690 | 4 | |
Chains E, Q and W: 46 helices, 38 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 22-39 | 18 | |
| α-helix | 46-49 | 4 | |
| β-strand | 63-64 | 2 | 28 |
| β-strand | 81-88 | 8 | 29 |
| α-helix | 89-90 | 2 | |
| α-helix | 91-95 | 5 | |
| β-strand | 104-109 | 6 | 30 |
| β-strand | 114-119 | 6 | 30 |
| β-strand | 122-127 | 6 | 30 |
| β-strand | 134-137 | 4 | 30 |
| β-strand | 146-150 | 5 | 31 |
| α-helix | 151-153 | 3 | |
| β-strand | 163-168 | 6 | 31 |
| β-strand | 172-180 | 9 | 31 |
| β-strand | 198-202 | 5 | 31 |
| β-strand | 208-209 | 2 | 31 |
| β-strand | 215-220 | 6 | 32 |
| β-strand | 226-230 | 5 | 32 |
| β-strand | 236-238 | 3 | 32 |
| β-strand | 255-256 | 2 | 32 |
| β-strand | 279-285 | 7 | 33 |
| β-strand | 290-295 | 6 | 33 |
| β-strand | 300-306 | 7 | 33 |
| β-strand | 309-311 | 3 | 33 |
| β-strand | 317-318 | 2 | 33 |
| α-helix | 320-327 | 8 | |
| β-strand | 344-347 | 4 | 34 |
| β-strand | 356-361 | 6 | 34 |
| β-strand | 367-371 | 5 | 34 |
| β-strand | 375 | 1 | 35 |
| β-strand | 381 | 1 | 35 |
| β-strand | 386-391 | 6 | 34 |
| β-strand | 406 | 1 | 28 |
| β-strand | 411-413 | 3 | 28 |
| β-strand | 417-423 | 7 | 28 |
| β-strand | 429-436 | 8 | 28 |
| β-strand | 447-452 | 6 | 28 |
| β-strand | 460-463 | 4 | 29 |
| α-helix | 496-498 | 3 | |
| β-strand | 499-503 | 5 | 29 |
| β-strand | 507-513 | 7 | 29 |
| α-helix | 514-515 | 2 | |
| α-helix | 516-522 | 7 | |
| α-helix | 536-542 | 7 | |
| α-helix | 544-556 | 13 | |
| α-helix | 564-576 | 13 | |
| α-helix | 661-679 | 19 | |
| β-strand | 681 | 1 | 36 |
| β-strand | 683 | 1 | 37 |
| β-strand | 700 | 1 | 37 |
| α-helix | 704-723 | 20 | |
| α-helix | 725-728 | 4 | |
| α-helix | 770-800 | 31 | |
| α-helix | 803-810 | 8 | |
| α-helix | 815-819 | 5 | |
| β-strand | 822 | 1 | 36 |
| α-helix | 823-827 | 5 | |
| α-helix | 831-843 | 13 | |
| α-helix | 850-862 | 13 | |
| α-helix | 872-886 | 15 | |
| α-helix | 899-907 | 9 | |
| α-helix | 912-922 | 11 | |
| α-helix | 926-940 | 15 | |
| α-helix | 945-952 | 8 | |
| α-helix | 962-982 | 21 | |
| α-helix | 1016-1024 | 9 | |
| α-helix | 1035-1046 | 12 | |
| α-helix | 1049-1054 | 6 | |
| α-helix | 1060-1067 | 8 | |
| α-helix | 1077-1087 | 11 | |
| α-helix | 1091-1103 | 13 | |
| α-helix | 1111-1123 | 13 | |
| α-helix | 1140-1163 | 24 | |
| α-helix | 1173-1180 | 8 | |
| α-helix | 1185-1186 | 2 | |
| α-helix | 1187-1193 | 7 | |
| α-helix | 1199-1209 | 11 | |
| α-helix | 1214-1231 | 18 | |
| α-helix | 1237-1255 | 19 | |
| α-helix | 1264-1276 | 13 | |
| α-helix | 1284-1292 | 9 | |
| α-helix | 1296-1309 | 14 | |
| α-helix | 1321-1336 | 16 | |
| α-helix | 1356-1363 | 8 | |
Chains F, L, R and X: 14 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 129-140 | 12 | |
| β-strand | 154-157 | 4 | 38 |
| β-strand | 191-195 | 5 | 39 |
| α-helix | 199-204 | 6 | |
| α-helix | 206-216 | 11 | |
| β-strand | 224-232 | 9 | 39 |
| β-strand | 238-247 | 10 | 39 |
| β-strand | 253-255 | 3 | 39 |
| α-helix | 256-257 | 2 | |
| α-helix | 258-265 | 8 | |
| α-helix | 268-277 | 10 | |
| β-strand | 279-284 | 6 | 39 |
| α-helix | 291-297 | 7 | |
| α-helix | 306-315 | 10 | |
| β-strand | 323-326 | 4 | 38 |
| α-helix | 329-396 | 68 | |
| α-helix | 407-421 | 15 | |
| α-helix | 422-426 | 5 | |
| α-helix | 427-450 | 24 | |
| α-helix | 455-457 | 3 | |
| β-strand | 461 | 1 | 40 |
| α-helix | 463-490 | 28 | |
Chains G, M, S and Y: 6 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 249-275 | 27 | |
| α-helix | 279-321 | 43 | |
| α-helix | 326-328 | 3 | |
| α-helix | 331-334 | 4 | |
| α-helix | 342-376 | 35 | |
| α-helix | 383-417 | 35 | |
Chains H, N, T and Z: 5 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 335-405 | 71 | |
| α-helix | 411-422 | 12 | |
| α-helix | 432-460 | 29 | |
| α-helix | 471-498 | 28 | |
| α-helix | 499-501 | 3 | |
Chains I and U: 37 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-16 | 12 | |
| α-helix | 33-41 | 9 | |
| α-helix | 177-198 | 22 | |
| α-helix | 204-212 | 9 | |
| α-helix | 220-229 | 10 | |
| α-helix | 254-274 | 21 | |
| α-helix | 289-299 | 11 | |
| β-strand | 312-313 | 2 | 41 |
| β-strand | 316-317 | 2 | 41 |
| α-helix | 318-328 | 11 | |
| α-helix | 331-340 | 10 | |
| α-helix | 347-352 | 6 | |
| α-helix | 369-374 | 6 | |
| α-helix | 375-379 | 5 | |
| α-helix | 385-395 | 11 | |
| α-helix | 410-420 | 11 | |
| α-helix | 437-446 | 10 | |
| α-helix | 449-452 | 4 | |
| α-helix | 462-469 | 8 | |
| α-helix | 472-479 | 8 | |
| α-helix | 486-498 | 13 | |
| α-helix | 528-539 | 12 | |
| α-helix | 544-552 | 9 | |
| α-helix | 553-556 | 4 | |
| α-helix | 562-577 | 16 | |
| α-helix | 580-584 | 5 | |
| β-strand | 585-586 | 2 | 42 |
| α-helix | 593 | 1 | |
| β-strand | 594-595 | 2 | 42 |
| α-helix | 597-601 | 5 | |
| α-helix | 606-619 | 14 | |
| α-helix | 624-632 | 9 | |
| α-helix | 635-646 | 12 | |
| α-helix | 663-675 | 13 | |
| α-helix | 683-701 | 19 | |
| α-helix | 707-717 | 11 | |
| α-helix | 729-735 | 7 | |
| α-helix | 739-759 | 21 | |
| α-helix | 761-763 | 3 | |
| α-helix | 787-798 | 12 | |
| α-helix | 809-813 | 5 | |
3 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Nuclear pore complex protein Nup155 | A, B, E, K, Q, W | protein | 1391 | Homo sapiens | O75694 (AlphaFold model) |
| Nuclear pore complex protein Nup93 | C, I, O, U | protein | 819 | Homo sapiens | Q8N1F7 (AlphaFold model) |
| Nuclear pore complex protein Nup205 | D, P | protein | 2012 | Homo sapiens | Q92621 (AlphaFold model) |
| Nucleoporin p54 | F, L, R, X | protein | 507 | Homo sapiens | Q7Z3B4 (AlphaFold model) |
| Nucleoporin p58/p45 | G, M, S, Y | protein | 599 | Homo sapiens | Q9BVL2 |
| Nuclear pore glycoprotein p62 | H, N, T, Z | protein | 522 | Homo sapiens | P37198 |
| Nucleoporin NUP188 homolog | J, V | protein | 1749 | Homo sapiens | Q5SRE5 |
Sequence of entity 1 (A, B, E, K, Q, W), FASTA
>5IJO_1 Nuclear pore complex protein Nup155 (chains A, B, E, K, Q, W)
MPSSLLGAAMPASTSAAALQEALENAGRLIDRQLQEDRMYPDLSELLMVSAPNNPTVSGM
SDMDYPLQGPGLLSVPNLPEISSIRRVPLPPELVEQFGHMQCNCMMGVFPPISRAWLTID
SDIFMWNYEDGGDLAYFDGLSETILAVGLVKPKAGIFQPHVRHLLVLATPVDIVILGLSY
ANLQTGSGVLNDSLSGGMQLLPDPLYSLPTDNTYLLTITSTDNGRIFLAGKDGCLYEVAY
QAEAGWFSQRCRKINHSKSSLSFLVPSLLQFTFSEDDPILQIAIDNSRNILYTRSEKGVI
QVYDLGQDGQGMSRVASVSQNAIVSAAGNIARTIDRSVFKPIVQIAVIENSESLDCQLLA
VTHAGVRLYFSTCPFRQPLARPNTLTLVHVRLPPGFSASSTVEKPSKVHRALYSKGILLM
AASENEDNDILWCVNHDTFPFQKPMMETQMTAGVDGHSWALSAIDELKVDKIITPLNKDH
IPITDSPVVVQQHMLPPKKFVLLSAQGSLMFHKLRPVDQLRHLLVSNVGGDGEEIERFFK
LHQEDQACATCLILACSTAACDREVSAWATRAFFRYGGEAQMRFPTTLPPPSNVGPILGS
PVYSSSPVPSGSPYPNPSFLGTPSHGIQPPAMSTPVCALGNPATQATNMSCVTGPEIVYS
GKHNGICIYFSRIMGNIWDASLVVERIFKSGNREITAIESSVPCQLLESVLQELKGLQEF
LDRNSQFAGGPLGNPNTTAKVQQRLIGFMRPENGNPQQMQQELQRKFHEAQLSEKISLQA
IQQLVRKSYQALALWKLLCEHQFTIIVAELQKELQEQLKITTFKDLVIRDKELTGALIAS
LINCYIRDNAAVDGISLHLQDICPLLYSTDDAICSKANELLQRSRQVQNKTEKERMLRES
LKEYQKISNQVDLSNVCAQYRQVRFYEGVVELSLTAAEKKDPQGLGLHFYKHGEPEEDIV
GLQAFQERLNSYKCITDTLQELVNQSKAAPQSPSVPKKPGPPVLSSDPNMLSNEEAGHHF
EQMLKLSQRSKDELFSIALYNWLIQVDLADKLLQVASPFLEPHLVRMAKVDQNRVRYMDL
LWRYYEKNRSFSNAARVLSRLADMHSTEISLQQRLEYIARAILSAKSSTAISSIAADGEF
LHELEEKMEVARIQLQIQETLQRQYSHHSSVQDAVSQLDSELMDITKLYGEFADPFKLAE
CKLAIIHCAGYSDPILVQTLWQDIIEKELSDSVTLSSSDRMHALSLKIVLLGKIYAGTPR
FFPLDFIVQFLEQQVCTLNWDVGFVIQTMNEIGVPLPRLLEVYDQLFKSRDPFWNRMKKP
LHLLDCIHVLLIRYVENPSQVLNCERRRFTNLCLDAVCGYLVELQSMSSSVAVQAITGNF
KSLQAKLERLH
Sequence of entity 2 (C, I, O, U), FASTA
>5IJO_2 Nuclear pore complex protein Nup93 (chains C, I, O, U)
MDTEGFGELLQQAEQLAAETEGISELPHVERNLQEIQQAGERLRSRTLTRTSQETADVKA
SVLLGSRGLDISHISQRLESLSAATTFEPLEPVKDTDIQGFLKNEKDNALLSAIEESRKR
TFGMAEEYHRESMLVEWEQVKQRILHTLLASGEDALDFTQESEPSYISDVGPPGRSSLDN
IEMAYARQIYIYNEKIVNGHLQPNLVDLCASVAELDDKSISDMWTMVKQMTDVLLTPATD
ALKNRSSVEVRMEFVRQALAYLEQSYKNYTLVTVFGNLHQAQLGGVPGTYQLVRSFLNIK
LPAPLPGLQDGEVEGHPVWALIYYCMRCGDLLAASQVVNRAQHQLGEFKTWFQEYMNSKD
RRLSPATENKLRLHYRRALRNNTDPYKRAVYCIIGRCDVTDNQSEVADKTEDYLWLKLNQ
VCFDDDGTSSPQDRLTLSQFQKQLLEDYGESHFTVNQQPFLYFQVLFLTAQFEAAVAFLF
RMERLRCHAVHVALVLFELKLLLKSSGQSAQLLSHEPGDPPCLRRLNFVRLLMLYTRKFE
STDPREALQYFYFLRDEKDSQGENMFLRCVSELVIESREFDMILGKLENDGSRKPGVIDK
FTSDTKPIINKVASVAENKGLFEEAAKLYDLAKNADKVLELMNKLLSPVVPQISAPQSNK
ERLKNMALSIAERYRAQGISANKFVDSTFYLLLDLITFFDEYHSGHIDRAFDIIERLKLV
PLNQESVEERVAAFRNFSDEIRHNLSEVLLATMNILFTQFKRLKGTSPSSSSRPQRVIED
RDSQLRSQARTLITFAGMIPYRTSGDTNARLVQMEVLMN
Sequence of entity 3 (D, P), FASTA
>5IJO_3 Nuclear pore complex protein Nup205 (chains D, P)
MATPLAVNSAASLWGPYKDIWHKVGNALWRRQPEAVHLLDKILKKHKPDFISLFKNPPKN
VQQHEKVQKASTEGVAIQGQQGTRLLPEQLIKEAFILSDLFDIGELAAVELLLAGEHQQP
HFPGLTRGLVAVLLYWDGKRCIANSLKALIQSRRGKTWTLELSPELASMTTRFTDELMEQ
GLTYKVLTLVSQIDVNNEFEKLQRERGLGSEKHRKEVSDLIKECRQSLAESLFAWACQSP
LGKEDTLLLIGHLERVTVEANGSLDAVNLALLMALLYCFDISFIEQSTEERDDMIHQLPL
LTEKQYIATIHSRLQDSQLWKLPGLQATVRLAWALALRGISQLPDVTALAEFTEADEAMA
ELAIADNVFLFLMESVVVSEYFYQEEFYIRRVHNLITDFLALMPMKVKQLRNRADEDARM
IHMSMQMGNEPPISLRRDLEHLMLLIGELYKKNPFHLELALEYWCPTEPLQTPTIMGSYL
GVAHQRPPQRQVVLSKFVRQMGDLLPPTIYIPYLKMLQGLANGPQCAHYCFSLLKVNGSS
HVENIQGAGGSPVSWEHFFHSLMLYHEHLRKDLPSADSVQYRHLPSRGITQKEQDGLIAF
LQLTSTIITWSENARLALCEHPQWTPVVVILGLLQCSIPPVLKAELLKTLAAFGKSPEIA
ASLWQSLEYTQILQTVRIPSQRQAIGIEVELNEIESRCEEYPLTRAFCQLISTLVESSFP
SNLGAGLRPPGFDPYLQFLRDSVFLRFRTRAYRRAAEKWEVAEVVLEVFYKLLRDYEPQL
EDFVDQFVELQGEEIIAYKPPGFSLMYHLLNESPMLELALSLLEEGVKQLDTYAPFPGKK
HLEKAVQHCLALLNLTLQKENLFMDLLRESQLALIVCPLEQLLQGINPRTKKADNVVNIA
RYLYHGNTNPELAFESAKILCCISCNSNIQIKLVGDFTHDQSISQKLMAGFVECLDCEDA
EEFVRLEEGSELEKKLVAIRHETRIHILNLLITSLECNPPNLALYLLGFELKKPVSTTNL
QDPGVLGCPRTCLHAILNILEKGTEGRTGPVAVRESPQLAELCYQVIYQLCACSDTSGPT
MRYLRTSQDFLFSQLQYLPFSNKEYEISMLNQMSWLMKTASIELRVTSLNRQRSHTQRLL
HLLLDDMPVKPYSDGEGGIEDENRSVSGFLHFDTATKVRRKILNILDSIDFSQEIPEPLQ
LDFFDRAQIEQVIANCEHKNLRGQTVCNVKLLHRVLVAEVNALQGMAAIGQRPLLMEEIS
TVLQYVVGRNKLLQCLHAKRHALESWRQLVEIILTACPQDLIQAEDRQLIIRDILQDVHD
KILDDEAAQELMPVVAGAVFTLTAHLSQAVLTEQKETSVLGPAEAHYAFMLDSCFTSPPP
EENPLVGFASIGDSSLYIILKKLLDFILKTGGGFQRVRTHLYGSLLYYLQIAQRPDEPDT
LEAAKKTMWERLTAPEDVFSKLQRENIAIIESYGAALMEVVCRDACDGHEIGRMLALALL
DRIVSVDKQQQWLLYLSNSGYLKVLVDSLVEDDRTLQSLLTPQPPLLKALYTYESKMAFL
TRVAKIQQGALELLRSGVIVRLAQCQVYDMRPETDPQSMFGMRDPPMFIPTPVDRYRQIL
LPALQLCQVILTSSMAQHLQAAGQVLQFLISHSDTIQAILRCQDVSAGSLQELALLTGII
SKAALPGILSELDVDVNEGSLMELQGHIGRFQRQCLGLLSRFGGSDRLRQFKFQDDNVEG
DKVSKKDEIELAMQQICANVMEYCQSLMLQSSPTFQHAVCLFTPSLSETVNRDGPRQDTQ
APVVPYWRLPGLGIIIYLLKQSANDFFSYYDSHRQSVSKLQNVEQLPPDEIKELCQSVMP
AGVDKISTAQKYVLARRRLVKVINNRAKLLSLCSFIIETCLFILWRHLEYYLLHCMPTDS
QDSLFASRTLFKSRRLQDSFASETNLDFRSGLAIVSQHDLDQLQADAINAFGESLQKKLL
DIEGLYSKVRSRYSFIQALVRRIRGLLRISRN
Sequence of entity 4 (F, L, R, X), FASTA
>5IJO_4 Nucleoporin p54 (chains F, L, R, X)
MAFNFGAPSGTSGTAAATAAPAGGFGGFGTTSTTAGSAFSFSAPTNTGTTGLFGGTQNKG
FGFGTGFGTTTGTSTGLGTGLGTGLGFGGFNTQQQQQTTLGGLFSQPTQAPTQSNQLINT
ASALSAPTLLGDERDAILAKWNQLQAFWGTGKGYFNNNIPPVEFTQENPFCRFKAVGYSC
MPSNKDEDGLVVLVFNKKETEIRSQQQQLVESLHKVLGGNQTLTVNVEGTKTLPDDQTEV
VIYVVERSPNGTSRRVPATTLYAHFEQANIKTQLQQLGVTLSMTRTELSPAQIKQLLQNP
PAGVDPIIWEQAKVDNPDSEKLIPVPMVGFKELLRRLKVQDQMTKQHQTRLDIISEDISE
LQKNQTTSVAKIAQYKRKLMDLSHRTLQVLIKQEIQRKSGYAIQADEEQLRVQLDTIQGE
LNAPTQFKGRLNELMSQIRMQNHFGAVRSEERYYIDADLLREIKQHLKQQQEGLSHLISI
IKDDLEDIKLVEHGLNETIHIRGGVFS
Sequence of entity 5 (G, M, S, Y), FASTA
>5IJO_5 Nucleoporin p58/p45 (chains G, M, S, Y)
MSTGFSFGSGTLGSTTVAAGGTSTGGVFSFGTGASSNPSVGLNFGNLGSTSTPATTSAPS
SGFGTGLFGSKPATGFTLGGTNTGIATTITTGLTLGTPATTSAATTGFSLGFNKPAASAT
PFALPITSTSASGLTLSSALTSTPAASTGFTLNNLGGTTATTTTASTGLSLGGALAGLGG
SLFQSTNTGTSGLGQNALGLTLGTTAATSTAGNEGLGGIDFSSSSDKKSDKTGTRPEDSK
ALKDENLPPVICQDVENLQKFVKEQKQVQEEISRMSSKAMLKVQEDIKALKQLLSLAANG
IQRNTLNIDKLKIETAQELKNAEIALRTQKTPPGLQHEYAAPADYFRILVQQFEVQLQQY
RQQIEELENHLATQANNSHITPQDLSMAMQKIYQTFVALAAQLQSIHENVKVLKEQYLGY
RKMFLGDAVDVFETRRAEAKKWQNTPRVTTGPTPFSTMPNAAAVAMAATLTQQQQPATGP
QPSLGVSFGTPFGSGIGTGLQSSGLGSSNLGGFGTSSGFGCSTTGASTFGFGTTNKPSGS
LSAGFGSSSTSGFNFSNPGITASAGLTFGVSNPASAGFGTGGQLLQLKKPPAGNKRGKR
Sequence of entity 6 (H, N, T, Z), FASTA
>5IJO_6 Nuclear pore glycoprotein p62 (chains H, N, T, Z)
MSGFNFGGTGAPTGGFTFGTAKTATTTPATGFSFSTSGTGGFNFGAPFQPATSTPSTGLF
SLATQTPATQTTGFTFGTATLASGGTGFSLGIGASKLNLSNTAATPAMANPSGFGLGSSN
LTNAISSTVTSSQGTAPTGFVFGPSTTSVAPATTSGGFSFTGGSTAQPSGFNIGSAGNSA
QPTAPATLPFTPATPAATTAGATQPAAPTPTATITSTGPSLFASIATAPTSSATTGLSLC
TPVTTAGAPTAGTQGFSLKAPGAASGTSTTTSTAATATATTTSSSSTTGFALNLKPLAPA
GIPSNTAAAVTAPPGPGAAAGAAASSAMTYAQLESLINKWSLELEDQERHFLQQATQVNA
WDRTLIENGEKITSLHREVEKVKLDQKRLDQELDFILSQQKELEDLLSPLEELVKEQSGT
IYLQHADEEREKTYKLAENIDAQLKRMAQDLKDIIEHLNTSGAPADTSDPLQQICKILNA
HMDSLQWIDQNSALLQRKVEEVTKVCEGRRKEQERSFRITFD
Sequence of entity 7 (J, V), FASTA
>5IJO_7 Nucleoporin NUP188 homolog (chains J, V)
MAAAAGGPCVRSSRELWTILLGRSALRELSQIEAELNKHWRRLLEGLSYYKPPSPSSAEK
VKANKDVASPLKELGLRISKFLGLDEEQSVQLLQCYLQEDYRGTRDSVKTVLQDERQSQA
LILKIADYYYEERTCILRCVLHLLTYFQDERHPYRVEYADCVDKLEKELVSKYRQQFEEL
YKTEAPTWETHGNLMTERQVSRWFVQCLREQSMLLEIIFLYYAYFEMAPSDLLVLTKMFK
EQGFGSRQTNRHLVDETMDPFVDRIGYFSALILVEGMDIESLHKCALDDRRELHQFAQDG
LICQDMDCLMLTFGDIPHHAPVLLAWALLRHTLNPEETSSVVRKIGGTAIQLNVFQYLTR
LLQSLASGGNDCTTSTACMCVYGLLSFVLTSLELHTLGNQQDIIDTACEVLADPSLPELF
WGTEPTSGLGIILDSVCGMFPHLLSPLLQLLRALVSGKSTAKKVYSFLDKMSFYNELYKH
KPHDVISHEDGTLWRRQTPKLLYPLGGQTNLRIPQGTVGQVMLDDRAYLVRWEYSYSSWT
LFTCEIEMLLHVVSTADVIQHCQRVKPIIDLVHKVISTDLSIADCLLPITSRIYMLLQRL
TTVISPPVDVIASCVNCLTVLAARNPAKVWTDLRHTGFLPFVAHPVSSLSQMISAEGMNA
GGYGNLLMNSEQPQGEYGVTIAFLRLITTLVKGQLGSTQSQGLVPCVMFVLKEMLPSYHK
WRYNSHGVREQIGCLILELIHAILNLCHETDLHSSHTPSLQFLCICSLAYTEAGQTVINI
MGIGVDTIDMVMAAQPRSDGAEGQGQGQLLIKTVKLAFSVTNNVIRLKPPSNVVSPLEQA
LSQHGAHGNNLIAVLAKYIYHKHDPALPRLAIQLLKRLATVAPMSVYACLGNDAAAIRDA
FLTRLQSKIEDMRIKVMILEFLTVAVETQPGLIELFLNLEVKDGSDGSKEFSLGMWSCLH
AVLELIDSQQQDRYWCPPLLHRAAIAFLHALWQDRRDSAMLVLRTKPKFWENLTSPLFGT
LSPPSETSEPSILETCALIMKIICLEIYYVVKGSLDQSLKDTLKKFSIEKRFAYWSGYVK
SLAVHVAETEGSSCTSLLEYQMLVSAWRMLLIIATTHADIMHLTDSVVRRQLFLDVLDGT
KALLLVPASVNCLRLGSMKCTLLLILLRQWKRELGSVDEILGPLTEILEGVLQADQQLME
KTKAKVFSAFITVLQMKEMKVSDIPQYSQLVLNVCETLQEEVIALFDQTRHSLALGSATE
DKDSMETDDCSRSRHRDQRDGVCVLGLHLAKELCEVDEDGDSWLQVTRRLPILPTLLTTL
EVSLRMKQNLHFTEATLHLLLTLARTQQGATAVAGAGITQSICLPLLSVYQLSTNGTAQT
PSASRKSLDAPSWPGVYRLSMSLMEQLLKTLRYNFLPEALDFVGVHQERTLQCLNAVRTV
QSLACLEEADHTVGFILQLSNFMKEWHFHLPQLMRDIQVNLGYLCQACTSLLHSRKMLQH
YLQNKNGDGLPSAVAQRVQRPPSAASAAPSSSKQPAADTEASEQQALHTVQYGLLKILSK
TLAALRHFTPDVCQILLDQSLDLAEYNFLFALSFTTPTFDSEVAPSFGTLLATVNVALNM
LGELDKKKEPLTQAVGLSTQAEGTRTLKSLLMFTMENCFYLLISQAMRYLRDPAVHPRDK
QRMKQELSSELSTLLSSLSRYFRRGAPSSPATGVLPSPQGKSTSLSKASPESQEPLIQLV
QAFVRHMQR
Primary citation
Molecular architecture of the inner ring scaffold of the human nuclear pore complex. Kosinski, J., Mosalaganti, S., von Appen, A. et al. Science (2016) 352:363-365. DOI 10.1126/science.aaf0643 · PubMed
Other PDB entries of the same protein (UniProt O75694 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 7R1Y 3.0 Å, cryoEM structure of human Nup155 (residues 19-981)
- 7EYE 5.1 Å, Cryo-EM (SPA) structure of Nup155 N-terminus (19-863) at 5.1 Angstrom resolution
- 7EYF 5.3 Å, Cryo-EM (SPA) structure of human Nup155 C-terminus (864-1337) at 5.3 Angstroms resolution
- 7EYQ 5.4 Å, Cryo-EM (SPA) structure of human Nup155 Longer N-terminus (19-1069) at 5.4 Angstrom…
- 7R5K 12.0 Å, Human nuclear pore complex (constricted)
- 5IJN 21.4 Å, Composite structure of the inner ring of the human nuclear pore complex (32 copies of…
- 5A9Q 23.0 Å, Human nuclear pore complex
- 7PER 35.0 Å, Model of the inner ring of the human nuclear pore complex
- 7R5J 50.0 Å, Human nuclear pore complex (dilated)
- 9A25 Molecular assembly pathway of the human Nuclear Pore Complex after cell division
- 9A8T Integrative spatiotemporal modeling of biomolecular processes: application to the…
Browse structure collections
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