Proto-oncogene FRAT1 (FRAT1) is a 279-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q92837.
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The mean pLDDT of this model is 59.8 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 12% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 41% |
| Below 50 | Very low: often disordered regions | 35% |
What pLDDT means and how to read it
Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis
Binds DVL1. Binds GSK-3 and prevent GSK-3-dependent phosphorylation
Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4AFJ | X-ray | 1.98 Å | X/Y=197-226 |
| 3ZRK | X-ray | 2.37 Å | X/Y=197-226 |
| 3ZRL | X-ray | 2.48 Å | X/Y=197-226 |
| 3ZRM | X-ray | 2.49 Å | X/Y=197-226 |
| 1GNG | X-ray | 2.6 Å | X/Y=188-226 |
| 5OY4 | X-ray | 3.2 Å | X/Y=1-279 |
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