1GNG: Glycogen synthase kinase-3 beta

Glycogen synthase kinase-3 beta (GSK3) complex with FRATtide peptide. Determined by X-ray diffraction at 2.6 Å resolution. Released 3 Oct 2002.

Method: X-ray diffraction
Resolution: 2.6 Å
Organism: HOMO SAPIENS
Chains: 4
Atoms: 6,227
Mol. weight: 95.85 kDa
Released: 3 Oct 2002

Explore 1GNG in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1GNG contains 45 α-helices and 26 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 21 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	38-44	7	1
β-strand	52-64	13	1
β-strand	69-75	7	1
β-strand	81-90	10	1
α-helix	96-103	8
β-strand	109	1	2
β-strand	112-118	7	1
β-strand	125-133	9	1
β-strand	138	1	2
α-helix	139-148	10
α-helix	155-174	20
β-strand	177-178	2	3
α-helix	184-186	3
β-strand	187-189	3	2
β-strand	196-198	3	2
β-strand	205-206	2	3
α-helix	220-222	3
α-helix	225-228	4
α-helix	237-252	16
α-helix	262-273	12
α-helix	276-277	2
α-helix	278-284	7
α-helix	297-300	4
α-helix	301-304	4
α-helix	311-320	10
α-helix	325-327	3
α-helix	329-330	2
α-helix	331-335	5
α-helix	338-344	7
α-helix	354-356	3
α-helix	364-367	4
α-helix	371-373	3
α-helix	374-377	4

Chain B: 20 helices, 14 β-strands

Element	Residues	Length	Sheet
β-strand	30	1	4
β-strand	36	1	4
β-strand	37-44	8	5
β-strand	52-63	12	5
β-strand	68-75	8	5
β-strand	81-90	10	5
α-helix	96-103	8
β-strand	109	1	6
β-strand	112-119	8	5
β-strand	125-133	9	5
β-strand	138	1	6
α-helix	139-148	10
α-helix	155-174	20
β-strand	177-178	2	7
α-helix	184-186	3
β-strand	187-189	3	6
β-strand	196-198	3	6
β-strand	205-206	2	7
α-helix	220-222	3
α-helix	225-228	4
α-helix	237-252	16
α-helix	262-273	12
α-helix	278-284	7
α-helix	297-300	4
α-helix	301-304	4
α-helix	311-318	8
α-helix	325-327	3
α-helix	329-330	2
α-helix	331-335	5
α-helix	338-344	7
α-helix	354-356	3
α-helix	364-367	4
α-helix	371-373	3
α-helix	374-377	4

Chain X: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	199-209	11
α-helix	212-221	10

Chain Y: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	199-209	11
α-helix	212-220	9

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Glycogen synthase kinase-3 beta	A, B	protein	378	HOMO SAPIENS	P49841 (AlphaFold model)
Frattide	X, Y	protein	39	HOMO SAPIENS	Q92837 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>1GNG_1 GLYCOGEN SYNTHASE KINASE-3 BETA (chains A, B)
MHHHHHHHHHHKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKL
CDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYV
PETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAV
LKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQP
IFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIA
LCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLAT
ILIPPHARIQAAASTPTN

Sequence of entity 2 (X, Y), FASTA

>1GNG_2 FRATTIDE (chains X, Y)
SQPETRTGDDDPHRLLQQLVLSGNLIKEAVRRLHSRRLQ

Primary citation

The Structure of Phosphorylated Gsk-3Beta Complexed with a Peptide, Frattide, that Inhibits Beta-Catenin Phosphorylation. Bax, B., Carter, P.S., Lewis, C. et al. Structure (2001) 9:1143. DOI 10.1016/S0969-2126(01)00679-7 · PubMed

Other PDB entries of the same protein (UniProt P49841 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9X2V 1.39 Å, GSK3beta complexed with BiS-3
1O6L 1.6 Å, Crystal structure of an activated Akt/protein kinase B (PKB-PIF chimera) ternary complex…
9X2Q 1.68 Å, GSK3beta complexed with BiS-1
1O6K 1.7 Å, Structure of activated form of PKB kinase domain S474D with GSK3 peptide and AMP-PNP
9X2X 1.79 Å, GSK3beta complexed with BiS-5
1J1B 1.8 Å, Binary complex structure of human tau protein kinase I with AMPPNP
2JDO 1.8 Å, Structure of pkb-beta (AKT2) complexed with isoquinoline-5-sulfonic acid…
7SXJ 1.85 Å, BIO-2895 (BRD0705) bound GSK3beta-axin complex
3QKL 1.9 Å, Spirochromane Akt Inhibitors
9X2W 1.92 Å, GSK3beta complexed with BiS-4
2X39 1.93 Å, Structure of 4-Amino-N-(4-chlorobenzyl)-1-(7H-pyrrolo(2,3-d)pyrimidin-…
1Q5K 1.94 Å, crystal structure of Glycogen synthase kinase 3 in complexed with inhibitor

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