Cullin-5 (CUL5) is a 780-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q93034.
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The mean pLDDT of this model is 89.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 70% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Core component of multiple cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes, also named CRL5 complexes), which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11384984, PubMed:15601820, PubMed:21199876, PubMed:21980433, PubMed:23897481, PubMed:25505247, PubMed:27910872, PubMed:32200094, PubMed:33268465, PubMed:35512830, PubMed:38418882, PubMed:40963025). Acts a scaffold protein that contributes to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:11384984, PubMed:15601820, PubMed:33268465). The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable…
Component of multiple cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes, also named CRL5 complexes) formed of CUL5, Elongin BC (ELOB and ELOC), RNF7/RBX2 and a variable SOCS box domain-containing protein as substrate-specific recognition component (PubMed:11384984, PubMed:15601820, PubMed:16325183, PubMed:21119685, PubMed:27910872, PubMed:32513959, PubMed:33268465,…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3DPL | X-ray | 2.6 Å | C=401-780 |
| 8EI2 | X-ray | 2.8 Å | A=1-386 |
| 9SDX | EM | 2.97 Å | C=1-780 |
| 3DQV | X-ray | 3.0 Å | C/D=401-780 |
| 4JGH | X-ray | 3.0 Å | D=10-386 |
| 9SDY | EM | 3.06 Å | C=1-780 |
| 8FVI | EM | 3.24 Å | x=11-320 |
| 4N9F | X-ray | 3.3 Å | 3/9/C/I/O/U/V/f/l/r/w/x=12-321 |
| 7ONI | EM | 3.4 Å | C=1-780 |
| 9EG1 | EM | 3.52 Å | J=1-780 |
| 8FVJ | EM | 3.54 Å | 2/7=12-320 |
| 9OMA | EM | 4.14 Å | B=1-780 |
| 6V9I | EM | 5.2 Å | C=2-780 |
| 9OMF | EM | 9.72 Å | B=1-780 |
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