Histone H2A type 1-C (H2AC6) is a 130-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q93077.
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The mean pLDDT of this model is 91.0 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 79% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7R5R | EM | 2.44 Å | C/G=1-130 |
| 8OX0 | EM | 2.52 Å | C/G=1-130 |
| 7PII | EM | 2.68 Å | C/G=1-130 |
| 7U46 | EM | 2.68 Å | C/G=1-130 |
| 8OOP | EM | 2.7 Å | O=2-130 |
| 8OX1 | EM | 2.7 Å | C/G=1-130 |
| 8OO7 | EM | 2.8 Å | O=2-130 |
| 9EOZ | EM | 3.1 Å | G/L=2-130 |
| 7A08 | EM | 3.11 Å | b/f=2-130 |
| 8OOA | EM | 3.18 Å | O=2-130 |
| 8X15 | EM | 3.2 Å | A/E=1-130 |
| 8X19 | EM | 3.2 Å | A/E=1-130 |
| 8X1C | EM | 3.2 Å | A/E=1-130 |
| 8OOS | EM | 3.29 Å | O=2-130 |
| 6MUP | EM | 3.5 Å | C/G=14-118 |
| 6MUO | EM | 3.6 Å | C/G=14-118 |
| 6C0W | EM | 4.0 Å | C/G=1-130 |
| 7Y8R | EM | 4.4 Å | C/G=2-130 |
| 6UPK | EM | 4.9 Å | C=1-130 |
| 6UPL | EM | 7.4 Å | C/K=1-130 |
Showing 20 of 24 experimental structures (best resolution first).
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