Chromo domain-containing protein LHP1 (LHP1) is a 445-residue protein from Arabidopsis thaliana. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q946J8.
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The mean pLDDT of this model is 60.2 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 19% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 28% |
| Below 50 | Very low: often disordered regions | 45% |
What pLDDT means and how to read it
Structural component of heterochromatin involved in gene repression, including several floral homeotic genes and FLT that regulates flowering time (PubMed:9611176). Required for maintenance of vernalization-induced repression of FLC. As part of the PRC1-like complex, recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me), leading to epigenetic repression. PcG PRC1 complex maintains the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Transcriptional repressor that binds…
Homodimer (PubMed:11731464). Interacts with CYP71 (PubMed:21596687). Interacts with histone H3 and CMT3 (PubMed:11898023). Interacts with SUVH (PubMed:15546353). Component of the PRC1-like complex, at least composed of RING1A, RING1B and LHP1 (PubMed:19097900). Binds to POL2A (PubMed:19097900). Interacts with DUF7/AIP1 (PubMed:26538092). Binds to LIF2 in the nucleus on a common set of chromatin…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7VYW | X-ray | 1.6 Å | A=106-160 |
| 7VZ2 | X-ray | 1.7 Å | A=106-160 |
| 8XAG | X-ray | 1.75 Å | A/B=99-162 |
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