Q96E40: Sperm acrosome-associated protein 9 (SPACA9)

Sperm acrosome-associated protein 9 (SPACA9) is a 222-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96E40.

Gene
SPACA9
Organism
Homo sapiens
Length
222 residues
Mean pLDDT
80.3
Model
AF-Q96E40-F1 v6
Model created
1 Aug 2025
PDB structures
3

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Model confidence (pLDDT)

The mean pLDDT of this model is 80.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.

pLDDT bandMeaningShare of residues
Above 90Very high: backbone and side chains are usually accurate67%
70 to 90Confident: backbone generally right4%
50 to 70Low: treat with caution7%
Below 50Very low: often disordered regions22%

What pLDDT means and how to read it

Function

Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) of multiciliated respiratory cells and the distal singlet microtubules of monoflagellated spermatozoa (PubMed:36191189). Forms an extensive interaction network cross-linking the lumen of axonemal doublet microtubules (By similarity)

Subunit structure

Microtubule inner protein component of sperm flagellar doublet microtubules (PubMed:36191189). Interacts with CABP1 and CALR (By similarity). Interacts with INCA1 (By similarity). Interacts with microtubules (By similarity) (PubMed:36191189)

Subcellular location

Cytoplasm, Cytoplasmic vesicle, secretory vesicle, acrosome, Cytoplasm, cytoskeleton, cilium basal body, Cytoplasm, cytoskeleton, flagellum axoneme, Cytoplasm, cytoskeleton, cilium axoneme, Nucleus

Experimental structures in the PDB

Compare the prediction with experimentally determined structures of the same protein:

PDB IDMethodResolutionChains and residues
7UNGEM3.6 ÅF0/F1/F2/F3/F4/F5/F6/F7/F8/G0/G1/G2/G3/G4/G5/G6/G7/G8/H0/H1/H2=1-222
8J07EM4.1 Å6A/6C/6E/6G/6I/6K/6L/6N/6O/6Q/6R/6T/6V=1-222
7UN1EM6.0 ÅA/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/d/e/f/g/h/i=1-222

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