7UNG: Protein CFAP95

48-nm repeat of the human respiratory doublet microtubule. Determined by electron microscopy at 3.6 Å resolution. Released 5 Oct 2022.

Method
Electron microscopy
Resolution
3.6 Å
Organism
Homo sapiens
Chains
435
Atoms
1,265,783
Mol. weight
20589.73 kDa
Ligands
GDP, MG, GTP
Released
5 Oct 2022

Explore 7UNG in 3D Show helices and sheets RCSB PDB PDBe

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Protein CFAP950, 7protein229Homo sapiensQ5VTT2 (AlphaFold model)
EF-hand domain-containing family member B1, 2protein833Homo sapiensQ8N7U6 (AlphaFold model)
Cilia- and flagella-associated protein 533, 4protein514Homo sapiensQ96M91 (AlphaFold model)
Nucleoside diphosphate kinase 75, 6protein376Homo sapiensQ9Y5B8 (AlphaFold model)
Protein CFAP1078, 9protein194Homo sapiensQ8N1D5
Protein CFAP141Aprotein101Homo sapiensQ5VU69
Tektin-1A0, A1, A2, A3, A4protein418Homo sapiensQ969V4
Tubulin alpha-1A chainAA, AC, AE, AG, AI, AK, AM, BA, BC, BE, BG, BI, BK, BM, CA, CC, CE, CG, CI, CK, CM, DA, DC, DE, DG, DI, DK, DM, EC, EE, EG, EI, EK, EM, FC, FE, FG, FI, FK, FM, GC, GE, GG, GI, GK, GM, HC, HE, HG, HI, HK, HM, HO, IC, IE, IG, II, IK, IM, IO, JC, JE, JG, JI, JK, JM, KC, KE, KG, KI, KK, KM, KO, LC, LE, LG, LI, LK, LM, MC, ME, MG, MI, MK, MM, NC, NE, NG, NI, NK, NM, OC, OE, OG, OI, OK, OM, OO, PC, PE, PG, PI, PK, PM, PO, QC, QE, QG, QI, QK, QM, QO, RC, RE, RG, RI, RK, RM, RO, SE, SG, SI, SK, SM, SO, TE, TG, TI, TK, TM, TO, UE, UG, UI, UK, UM, UO, VE, VG, VI, VK, VM, VO, WE, WG, WI, WK, WM, WOprotein451Homo sapiensQ71U36
Tubulin beta-4B chainAB, AD, AF, AH, AJ, AL, BB, BD, BF, BH, BJ, BL, CB, CD, CF, CH, CJ, CL, DB, DD, DF, DH, DJ, DL, EB, ED, EF, EH, EJ, EL, EN, FB, FD, FF, FH, FJ, FL, FN, GB, GD, GF, GH, GJ, GL, GN, HB, HD, HF, HH, HJ, HL, HN, IB, ID, IF, IH, IJ, IL, IN, JB, JD, JF, JH, JJ, JL, JN, KB, KD, KF, KH, KJ, KL, KN, LB, LD, LF, LH, LJ, LL, LN, MB, MD, MF, MH, MJ, ML, MN, NB, ND, NF, NH, NJ, NL, NN, OB, OD, OF, OH, OJ, OL, ON, PD, PF, PH, PJ, PL, PN, QD, QF, QH, QJ, QL, QN, RD, RF, RH, RJ, RL, RN, SD, SF, SH, SJ, SL, SN, TD, TF, TH, TJ, TL, TN, TP, UD, UF, UH, UJ, UL, UN, UP, VD, VF, VH, VJ, VL, VN, VP, WD, WF, WH, WJ, WL, WN, WPprotein445Homo sapiensP68371
Meiosis-specific nuclear structural protein 1B, Cprotein495Homo sapiensQ8NEH6
Tektin-2B0, B1, B2, B3, B4, B5, B6, B7, B8, B9protein430Homo sapiensQ9UIF3
Tektin-3C0, C1, C2, C3, C4protein490Homo sapiensQ9BXF9

23 more molecules are not listed.

Sequence of entity 1 (0, 7), FASTA
>7UNG_1 Protein CFAP95 (chains 0, 7)
MDSLDRSCQDWCDRKQHWLEIGPPDLVERKGSLTLRSHHKKYSKPVLVYSWHRDREAFPK
GYDIEGPEKVKKLCNSTYRRLGTDESPIWTSETHEKLSQMCLNTEWVEMKSKALLNEETV
SSGIIERVTGLPATGFGAVFPRHPPDWSKMCALTTYSEDYVPPYDYQPHAYPCQDDYSIV
HRKCRSQFTDLNGSKRFGINTWHDESGIYANSDVKQKLYPLTSGPIVPI
Sequence of entity 2 (1, 2), FASTA
>7UNG_2 EF-hand domain-containing family member B (chains 1, 2)
MNMEIGHPHEGKDDLGDKRVIMGTKFPMELGIRVGLGKEDSRCGESPVVSNKCEGRMAPP
ETKFPLSKGLEMGLERQNISRTVMQRGSLGVDSVSASQGTKPSLLPGRMGLENESLLAGY
THERIIQPPLGRVCGSSQAAGSRRAPLASGPEGVEELVGKPAFVMEPRQEMEKESTCVLM
KPNTEIKLPVEVDIGLTQAEGPDETKNTEPQMGLVIEPPQCQFAQQHEQRKEAGNIESGV
EPPDRIRPIYSGKFFDRTPCWPSAGKVIPVGYRVATCLTEKLPRLITPPEAKKYFNFRYP
PAGVERVFYGRANDPQIAPYLTHGIRSKISVLANTLINPQPITTFQQKIKDKKESIYLSN
RRAPLGKSHDQAPGLPKGMDTTNTTFGTAVIKEYSAKDVVNPPKSYEEVFKEGNEGHDLY
VVSHNDYYAGEAKNRKYNPSSFHRCSVYGVPTPHFNDGRAMAKSLYWLHELQMKRGAKFV
SKRADDFKEKFQHKLGRVLDPIAETMNVPPDCTFGACLRPEEYGVGDLIHNRLPDEYLRG
KDRQRALIAAVRHHLKKVNYQKFDTLLAAFRHYDKKGDGMIDKDELQEACDQANLSLDDK
LLDQLFDYCDVDNDGFINYLEFANFLNWKDKMLLKEYEERVIIKGRKPDCVNPTEANVEE
PEQTLLIKPEDIVLKEAGSTEKTLRTLLRPSDKVSNYYKTTSSEINAIVGAIPSTCYPIC
GVPTIRSDIPAPRIRRISDRTNYGEEGSAYSLLYPTIFARKGVFERDFFKTRSKEEIAEI
LCNIGVKLSDEEFENVWNLASKKHHRGEVCVENIRNVLDELRHADRIKCKTLM
Sequence of entity 3 (3, 4), FASTA
>7UNG_3 Cilia- and flagella-associated protein 53 (chains 3, 4)
MYSQRFGTVQREVKGPTPKVVIVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERD
RLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLALEENEYFTEMQLKK
ETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEER
KAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITS
IKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQ
QEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEF
DRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQK
HINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAAN
KMCLDKVQEVLSTHQVLPQNIHPMRKACPSKLPP
Sequence of entity 4 (5, 6), FASTA
>7UNG_4 Nucleoside diphosphate kinase 7 (chains 5, 6)
MNHSERFVFIAEWYDPNASLLRRYELLFYPGDGSVEMHDVKNHRTFLKRTKYDNLHLEDL
FIGNKVNVFSRQLVLIDYGDQYTARQLGSRKEKTLALIKPDAISKAGEIIEIINKAGFTI
TKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAICEWKRLLGPAN
SGVARTDASESIRALFGTDGIRNAAHGPDSFASAAREMELFFPSSGGCGPANTAKFTNCT
CCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGVVTEYHDMVT
EMYSGPCVAMEIQQNNATKTFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTDLP
EDGLLEVQYFFKILDN
Sequence of entity 5 (8, 9), FASTA
>7UNG_5 Protein CFAP107 (chains 8, 9)
MFLTAVNPQPLSTPSWQIETKYSTKVLTGNWMEERRKFTRDTDKTPQSIYRKEYIPFPDH
RPDQISRWYGKRKVEGLPYKHLITHHQEPPHRYLISTYDDHYNRHGYNPGLPPLRTWNGQ
KLLWLPEKSDFPLLAPPTNYGLYEQLKQRQLTPKAGLKQSTYTSSYPRPPLCAMSWREHA
VPVPPHRLHPFPHF
Sequence of entity 6 (A), FASTA
>7UNG_6 Protein CFAP141 (chains A)
MSVEKMTKVEESFQKAMGLKKTVDRWRNSHTHCLWQMALGQRRNPYATLRMQDTMVQELA
LAKKQLLMVRQAALHQLFEKEHQQYQQELNQMGKAFYVERF
Sequence of entity 7 (A0, A1, A2, A3, A4), FASTA
>7UNG_7 Tektin-1 (chains A0, A1, A2, A3, A4)
MAKLLQPPPKFLPSEWHIANKNQYHRADAQRSRSERLVAESQRLVDEIEKTTRKSQSDVN
KKLEQRLEEVQFWKKELDDKLEQLVNVTDDLLIYKIRLEKALETLKEPLHITETCLAYRE
KRIGIDLVHDTVEHELIKEAEIIQGIMALLTRTLEEASEQIRMNRSAKYNLEKDLKDKFV
ALTIDDICFSLNNNSPNIRYSENAVRIEPNSVSLEDWLDFSSTNVEKADKQRNNSLMLKA
LVDRILSQTANDLRKQCDVVDTAFKNGLKDTKDARDKLADHLAKVMEEIASQEKNITALE
KAILDQEGPAKVAHTRLETRTHRPNVELCRDVAQYRLMKEVQEITHNVARLKETLAQAQA
ELKGLHRRQLALQEEIQVKENTIYIDEVLCMQMRKSIPLRDGEDHGVWAGGLRPDAVC
Sequence of entity 8 (AA, AC, AE, AG, AI, AK, AM, BA, BC, BE, BG, BI, BK, BM, CA, CC, CE, CG, CI, CK, CM, DA, DC, DE, DG, DI, DK, DM, EC, EE, EG, EI, EK, EM, FC, FE, FG, FI, FK, FM, GC, GE, GG, GI, GK, GM, HC, HE, HG, HI, HK, HM, HO, IC, IE, IG, II, IK, IM, IO, JC, JE, JG, JI, JK, JM, KC, KE, KG, KI, KK, KM, KO, LC, LE, LG, LI, LK, LM, MC, ME, MG, MI, MK, MM, NC, NE, NG, NI, NK, NM, OC, OE, OG, OI, OK, OM, OO, PC, PE, PG, PI, PK, PM, PO, QC, QE, QG, QI, QK, QM, QO, RC, RE, RG, RI, RK, RM, RO, SE, SG, SI, SK, SM, SO, TE, TG, TI, TK, TM, TO, UE, UG, UI, UK, UM, UO, VE, VG, VI, VK, VM, VO, WE, WG, WI, WK, WM, WO), FASTA
>7UNG_8 Tubulin alpha-1A chain (chains AA, AC, AE, AG, AI, AK, AM, BA, BC, BE, BG, BI, BK, BM, CA, CC, CE, CG, CI, CK, CM, DA, DC, DE, DG, DI, DK, DM, EC, EE, EG, EI, EK, EM, FC, FE, FG, FI, FK, FM, GC, GE, GG, GI, GK, GM, HC, HE, HG, HI, HK, HM, HO, IC, IE, IG, II, IK, IM, IO, JC, JE, JG, JI, JK, JM, KC, KE, KG, KI, KK, KM, KO, LC, LE, LG, LI, LK, LM, MC, ME, MG, MI, MK, MM, NC, NE, NG, NI, NK, NM, OC, OE, OG, OI, OK, OM, OO, PC, PE, PG, PI, PK, PM, PO, QC, QE, QG, QI, QK, QM, QO, RC, RE, RG, RI, RK, RM, RO, SE, SG, SI, SK, SM, SO, TE, TG, TI, TK, TM, TO, UE, UG, UI, UK, UM, UO, VE, VG, VI, VK, VM, VO, WE, WG, WI, WK, WM, WO)
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD
RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGVDSVEGEGEEEGEEY
Sequence of entity 9 (AB, AD, AF, AH, AJ, AL, BB, BD, BF, BH, BJ, BL, CB, CD, CF, CH, CJ, CL, DB, DD, DF, DH, DJ, DL, EB, ED, EF, EH, EJ, EL, EN, FB, FD, FF, FH, FJ, FL, FN, GB, GD, GF, GH, GJ, GL, GN, HB, HD, HF, HH, HJ, HL, HN, IB, ID, IF, IH, IJ, IL, IN, JB, JD, JF, JH, JJ, JL, JN, KB, KD, KF, KH, KJ, KL, KN, LB, LD, LF, LH, LJ, LL, LN, MB, MD, MF, MH, MJ, ML, MN, NB, ND, NF, NH, NJ, NL, NN, OB, OD, OF, OH, OJ, OL, ON, PD, PF, PH, PJ, PL, PN, QD, QF, QH, QJ, QL, QN, RD, RF, RH, RJ, RL, RN, SD, SF, SH, SJ, SL, SN, TD, TF, TH, TJ, TL, TN, TP, UD, UF, UH, UJ, UL, UN, UP, VD, VF, VH, VJ, VL, VN, VP, WD, WF, WH, WJ, WL, WN, WP), FASTA
>7UNG_9 Tubulin beta-4B chain (chains AB, AD, AF, AH, AJ, AL, BB, BD, BF, BH, BJ, BL, CB, CD, CF, CH, CJ, CL, DB, DD, DF, DH, DJ, DL, EB, ED, EF, EH, EJ, EL, EN, FB, FD, FF, FH, FJ, FL, FN, GB, GD, GF, GH, GJ, GL, GN, HB, HD, HF, HH, HJ, HL, HN, IB, ID, IF, IH, IJ, IL, IN, JB, JD, JF, JH, JJ, JL, JN, KB, KD, KF, KH, KJ, KL, KN, LB, LD, LF, LH, LJ, LL, LN, MB, MD, MF, MH, MJ, ML, MN, NB, ND, NF, NH, NJ, NL, NN, OB, OD, OF, OH, OJ, OL, ON, PD, PF, PH, PJ, PL, PN, QD, QF, QH, QJ, QL, QN, RD, RF, RH, RJ, RL, RN, SD, SF, SH, SJ, SL, SN, TD, TF, TH, TJ, TL, TN, TP, UD, UF, UH, UJ, UL, UN, UP, VD, VF, VH, VJ, VL, VN, VP, WD, WF, WH, WJ, WL, WN, WP)
MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYV
PRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEGEFEEEAEEEVA
Sequence of entity 10 (B, C), FASTA
>7UNG_10 Meiosis-specific nuclear structural protein 1 (chains B, C)
MGSKRRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLL
QNEQFELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIE
LRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKR
NKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNA
MRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQN
ALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMAL
KELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFL
ADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHATNLLGYLPKGVFKKEDDIDLLGEE
FRKVYQQRSEICEEK
Sequence of entity 11 (B0, B1, B2, B3, B4, B5, B6, B7, B8, B9), FASTA
>7UNG_11 Tektin-2 (chains B0, B1, B2, B3, B4, B5, B6, B7, B8, B9)
MATLSVKPSRRFQLPDWHTNSYLLSTNAQLQRDASHQIRQEARVLRNETNNQTIWDEHDN
RTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLR
ESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKM
ETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELR
EATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHL
EEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQ
DALDALCKHLARLQADIACKANSMLLDTKCMDTRRKLTVPAERFVPEVDTFTRTTNSTLS
PLKSCQLELA
Sequence of entity 12 (C0, C1, C2, C3, C4), FASTA
>7UNG_12 Tektin-3 (chains C0, C1, C2, C3, C4)
MERVGCTLTTTYAHPRPTPTNFLPAISTMASSYRDRFPHSNLTHSLSLPWRPSTYYKVAS
NSPSVAPYCTRSQRVSENTMLPFVSNRTTFFTRYTPDDWYRSNLTNYQESNTSRHNSEKL
RVDTSRLIQDKYQQTRKTQADTTQNLGERVNDIGFWKSEIIHELDEMIGETNALTDVKKR
LERALMETEAPLQVARECLFHREKRMGIDLVHDEVEAQLLTEVDTILCCQERMKLHLDKA
IAQLAANRASQHELEKDLSDKQTAYRIDDKCHHLRNTSDGVGYFRGVERVDATVSVPESW
AKFTDDNILRSQSERAASAKLRDDIENLLVVTANEMWNQFNKVNLSFTNRIAETADAKNK
IQTHLAKTLQEIFQTEMTIESIKKAIKDKTAFLKVAQTRLDERTRRPNIELCRDMAQLRL
VNEVHEVDDTIQTLQQRLRDAEDTLQSLVHIKATLEYDLAVKANSLYIDQEKCMSMRKSY
PNTLRLVGFC

Ligands and cofactors

IDNameFormulaCopies
GDPGuanosine-5'-diphosphateC10 H15 N5 O11 P2153
MGMagnesium ionMg149
GTPGuanosine-5'-triphosphateC10 H16 N5 O14 P3149

Primary citation

SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules. Gui, M., Croft, J.T., Zabeo, D. et al. Proc Natl Acad Sci U S A (2022) 119:e2207605119-e2207605119. DOI 10.1073/pnas.2207605119 · PubMed

Other PDB entries of the same protein (UniProt Q5VTT2 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

About this viewer

MolViewer shows 7UNG directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.