Zinc finger protein 512B (ZNF512B) is a 892-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96KM6.
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The mean pLDDT of this model is 57.0 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 4% |
| 70 to 90 | Confident: backbone generally right | 30% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 57% |
What pLDDT means and how to read it
Involved in transcriptional regulation by repressing gene expression (PubMed:39460621). Associates with the nucleosome remodeling and histone deacetylase (NuRD) complex, which promotes transcriptional repression by histone deacetylation and nucleosome remodeling (PubMed:39460621). Sequence-specific DNA-binding protein that recognizes repetitive and non-consecutive TTC sequences in pericentric repeat and initiate heterochromatin formation through interaction with SUV39H1/2 methyltransferases which catalyze histone H3K9 methylation (By similarity)
Interacts (via its NuRD interaction motif) with RBBP4 of the nucleosome remodeling and deacetylase (NuRD) complex; the interaction is direct and may play a role in repressing gene expression
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
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