Nectin-4 (NECTIN4) is a 510-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96NY8.
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The mean pLDDT of this model is 79.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 53% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 16% |
What pLDDT means and how to read it
Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells
Self-associates. Interacts via its Ig-like V-type domain with NECTIN1 Ig-like V-type domain. Interacts via its C-terminus with AFDN
Cell membrane, Cell junction, adherens junction, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4JJH | X-ray | 2.25 Å | A/B=32-153 |
| 9UCL | EM | 2.43 Å | G/H/I=32-146 |
| 4GJT | X-ray | 3.1 Å | B/C=32-146 |
| 9KKJ | EM | 3.26 Å | A=32-145 |
| 4FRW | X-ray | 3.5 Å | A/B/C/D/E/F=32-243 |
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