Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1) is a 1450-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96P48.
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The mean pLDDT of this model is 74.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 40% |
| 70 to 90 | Confident: backbone generally right | 31% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 24% |
What pLDDT means and how to read it
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members (PubMed:11804590, PubMed:19666464). Activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding and, to a lesser extent, by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) binding (PubMed:11804590). Has a preference for ARF1 and ARF5 (PubMed:11804590, PubMed:19666464). Positively regulates the ring size of circular dorsal ruffles and promotes macropinocytosis (PubMed:22573888). Acts as a bridging factor in osteoclasts to control actin and membrane dynamics (By similarity). Regulates the condensing of…
Interacts with SH3KBP1/CIN85 (via SH3 domains) (PubMed:21275903). The interaction is independent of EGF and does not affect ARAP1 GTPase-activating activity but is involved in regulating ubiquitination and endocytic trafficking of EGFR (PubMed:21275903). ARAP1 competes with E3 ubiquitin-protein ligase CBL for binding to SH3KBP1, preventing interaction of CBL with SH3KBP1; this is likely to…
Cytoplasm, Golgi apparatus, trans-Golgi network, Golgi apparatus, Golgi stack, Cell membrane, Endosome, multivesicular body, Cell projection, ruffle, Cell projection, podosome, Early endosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4X1V | X-ray | 1.58 Å | B=76-91 |
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