Rab-3A-interacting protein (RAB3IP) is a 476-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96QF0.
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The mean pLDDT of this model is 70.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 48% |
| 70 to 90 | Confident: backbone generally right | 6% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 37% |
What pLDDT means and how to read it
Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B (PubMed:12221131, PubMed:26824392). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:12221131, PubMed:26824392). Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5 (PubMed:20937701, PubMed:26824392). Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface (PubMed:12221131). Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and…
Homodimer (PubMed:26258637). Interacts with the N-terminal region of SSX2 (PubMed:12007189). Interacts with the GDP-bound forms of RAB8A and RAB8B (PubMed:12221131, PubMed:26824392). The interaction with RAB8A is prevented by phosphorylation of RAB8A at 'Thr-72' (PubMed:26824392). Interacts with the GDP-bound forms of RAB3A and RAB3D (PubMed:12221131). Interacts with DCDC1 (PubMed:12007189,…
Cytoplasm, Nucleus, Cytoplasm, cytoskeleton, Cell projection, lamellipodium, Vesicle, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6F6P | X-ray | 2.45 Å | A/B/C/D=159-261 |
| 4UJ5 | X-ray | 2.6 Å | C/D=286-476 |
| 4UJ3 | X-ray | 3.0 Å | B/E/H/K/N/Q/T/W=286-476 |
| 4LHX | X-ray | 3.05 Å | C/D/E/F=173-248 |
| 4LHY | X-ray | 3.1 Å | C/D/E/F=173-248 |
| 4LHZ | X-ray | 3.2 Å | C/D/E/F=173-248 |
| 4UJ4 | X-ray | 4.2 Å | B/E/H/K=286-476 |
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