Tribbles homolog 1 (TRIB1) is a 372-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96RU8.
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The mean pLDDT of this model is 76.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 57% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 27% |
What pLDDT means and how to read it
Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596). The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases,…
Monomer (PubMed:26455797). Interacts (via protein kinase domain) with CEBPA (PubMed:20410507, PubMed:26455797). Interacts with COP1 (PubMed:20410507, PubMed:27041596)
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5IGO | X-ray | 1.6 Å | U/V/W/X=354-361 |
| 5CEM | X-ray | 2.1 Å | A=83-371 |
| 5CEK | X-ray | 2.8 Å | A=83-343 |
| 6DC0 | X-ray | 2.8 Å | A/B=90-343 |
| 5IGQ | X-ray | 3.9 Å | U=354-364, V/W/X/Y/Z=354-361 |
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