SRSF protein kinase 1 (SRPK1) is a 655-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96SB4.
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The mean pLDDT of this model is 70.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 50% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 36% |
What pLDDT means and how to read it
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2,…
Monomer. Isoform 2 is found in a multisubunit complex containing seven proteins, named toposome, which separates entangled circular chromatin DNA during chromosome segregation. Isoform 2 interacts with DNAJC8 and AHSA1/AHA1 and this mediates formation of a complex with the Hsp70 /Hsp90 machinery. Isoform 1 is found in a complex with: DHX9, MOV10, MATR3, HNRNPU, NCL, DDX21, HSD17B4, PABPC1,…
Cytoplasm, Nucleus, Nucleus matrix, Microsome, Nucleus, nucleoplasm, Nucleus speckle, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5NNG | X-ray | 1.2 Å | B=582-591 |
| 5MY8 | X-ray | 1.7 Å | A=58-255, A=474-655 |
| 1WAK | X-ray | 1.73 Å | A=42-655 |
| 5MXX | X-ray | 1.75 Å | A=40-655 |
| 4WUA | X-ray | 2.0 Å | A=42-255, A=474-655 |
| 7DD1 | X-ray | 2.05 Å | A=58-255, A=474-655 |
| 7PQS | X-ray | 2.2 Å | A/B=58-655 |
| 7ZKS | X-ray | 2.28 Å | A=50-655 |
| 5XV7 | X-ray | 2.32 Å | A=67-655 |
| 1WBP | X-ray | 2.4 Å | A=42-655 |
| 6FAD | X-ray | 2.8 Å | A/B/C/D=42-655 |
| 3BEG | X-ray | 2.9 Å | A=58-255, A=474-655 |
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