Protein artemis (DCLRE1C) is a 692-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96SD1.
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The mean pLDDT of this model is 69.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 46% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 40% |
What pLDDT means and how to read it
Nuclease involved in DNA non-homologous end joining (NHEJ); required for double-strand break repair and V(D)J recombination (PubMed:11336668, PubMed:11955432, PubMed:12055248, PubMed:14744996, PubMed:15071507, PubMed:15574326, PubMed:15936993). Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments (PubMed:11336668, PubMed:11955432, PubMed:14744996). V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs) (PubMed:11336668, PubMed:11955432,…
Interacts with LIG4; the interaction is direct (PubMed:23219551, PubMed:23523427). Interacts with ATM (PubMed:15456891). Interacts with BRCA1 (PubMed:15456891). Interacts with PRKDC (PubMed:11955432, PubMed:14744996, PubMed:15456891, PubMed:15936993). Interacts with TP53BP1 (PubMed:15574327). Also exhibits ATM- and phosphorylation-dependent interaction with the MRN complex, composed of MRE11,…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6TT5 | X-ray | 1.5 Å | AAA=1-361 |
| 7AFU | X-ray | 1.56 Å | A=1-361 |
| 7AF1 | X-ray | 1.7 Å | A=1-361 |
| 7AFS | X-ray | 1.7 Å | A=1-361 |
| 7AGI | X-ray | 1.7 Å | A=1-361 |
| 7APV | X-ray | 1.95 Å | A=1-361 |
| 6WO0 | X-ray | 1.97 Å | A=2-368 |
| 7ABS | X-ray | 1.97 Å | A=2-368 |
| 4HTP | X-ray | 2.25 Å | C/E=485-495 |
| 6WNL | X-ray | 2.37 Å | A/B=2-368 |
| 3W1B | X-ray | 2.4 Å | B=485-495 |
| 3W1G | X-ray | 2.55 Å | B=485-495 |
| 7SGL | EM | 3.0 Å | D=1-692 |
| 7TYR | EM | 3.33 Å | C=1-692 |
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