E3 ubiquitin-protein ligase RING2 (RNF2) is a 336-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q99496.
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The mean pLDDT of this model is 77.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 43% |
| 70 to 90 | Confident: backbone generally right | 29% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 20% |
What pLDDT means and how to read it
E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15386022, PubMed:16359901, PubMed:21772249, PubMed:25355358, PubMed:25519132, PubMed:26151332, PubMed:33864376). H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation (By similarity). Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes,…
Component of chromatin-associated Polycomb (PcG) complexes. Component of a number of PRC1-like complexes; these complexes contain either the polycomb group ring finger protein PCGF1, or PCGF2, or PCGF3, or PCGF4, or PCGF5, or PCGF6 (PubMed:12167701, PubMed:15386022, PubMed:19636380, PubMed:21282530, PubMed:26151332, PubMed:26687479). Part of a complex that contains RNF2, UB2D3 and BMI1; within…
Nucleus, Cytoplasm, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3GS2 | X-ray | 1.7 Å | A/C=223-333 |
| 3IXS | X-ray | 1.7 Å | A/C/E/G/I/K=223-333 |
| 6WI7 | X-ray | 1.7 Å | A=10-116 |
| 3H8H | X-ray | 2.0 Å | A=220-330 |
| 4S3O | X-ray | 2.0 Å | B/E=1-116 |
| 2H0D | X-ray | 2.5 Å | B=15-114 |
| 3RPG | X-ray | 2.65 Å | C=1-116 |
| 9DBY | EM | 2.8 Å | L=1-336 |
| 8PP7 | EM | 2.91 Å | L/N=1-336 |
| 9DGG | EM | 2.98 Å | L=1-336 |
| 8GRM | EM | 3.05 Å | N=16-116 |
| 6WI8 | X-ray | 3.09 Å | A/B=10-116 |
| 9DDE | EM | 3.2 Å | L=1-336 |
| 4R8P | X-ray | 3.28 Å | L/N=2-116 |
| 7ND1 | NMR | A=10-116 |
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