Sortilin (SORT1) is a 831-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q99523.
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The mean pLDDT of this model is 82.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 66% |
| 70 to 90 | Confident: backbone generally right | 15% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 17% |
What pLDDT means and how to read it
Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:16787399). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the…
Interacts with LPL and SLC2A4 (By similarity). Interacts with the cytosolic adapter proteins GGA1 and GGA2 (PubMed:16787399, PubMed:20015111). Interacts with numerous ligands including the receptor-associated protein LRPAP1/RAP, GM2A and NTS. Forms a complex with NGFR which binds specifically to the precursor forms of NGFB (proNGFB) and BDNF (proBDNF). Interacts with the Trk receptors NTRK1,…
Golgi apparatus, Golgi stack membrane, Endosome membrane, Endoplasmic reticulum membrane, Nucleus membrane, Cell membrane, Lysosome membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3F6K | X-ray | 2.0 Å | A=78-756 |
| 5MRI | X-ray | 2.0 Å | A=78-756 |
| 3G2V | X-ray | 2.1 Å | C/D=819-831 |
| 3G2U | X-ray | 2.3 Å | C/D=819-831 |
| 5MRH | X-ray | 2.5 Å | A=78-756 |
| 4PO7 | X-ray | 2.66 Å | A=78-756 |
| 4MSL | X-ray | 2.7 Å | A=78-756 |
| 4N7E | X-ray | 2.7 Å | A=78-756 |
| 6X3L | X-ray | 2.7 Å | A=1-756 |
| 9R18 | X-ray | 2.8 Å | A=1-756 |
| 8T8R | X-ray | 2.87 Å | A=79-756 |
| 6X48 | X-ray | 2.9 Å | A=86-748 |
| 6X4H | X-ray | 2.9 Å | A=86-748 |
| 8T8S | X-ray | 2.99 Å | A/B=79-756 |
| 9I0N | EM | 3.1 Å | A=34-756 |
| 9I0O | EM | 3.36 Å | A=34-756 |
| 6EHO | X-ray | 3.5 Å | A=34-756 |
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