Cell division control protein 6 homolog (CDC6) is a 560-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q99741.
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The mean pLDDT of this model is 69.7 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 25% |
| 70 to 90 | Confident: backbone generally right | 36% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 30% |
What pLDDT means and how to read it
Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated
Interacts with PCNA, ORC1, cyclin-CDK (PubMed:9566895). Interacts with HUWE1 (PubMed:17567951). Interacts with ANKRD17 (PubMed:23711367). Interacts with GRWD1; origin binding of GRWD1 is dependent on CDC6 (PubMed:25990725). Interacts with CDT1; are mutually dependent on one another for loading MCM complexes onto chromatin (PubMed:14672932). Interacts with TTC4 (PubMed:18320024). Interacts (via…
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2CCH | X-ray | 1.7 Å | E/F=89-100 |
| 4I5L | X-ray | 2.43 Å | B/E=70-90 |
| 2CCI | X-ray | 2.7 Å | F/I=71-100 |
| 4I5N | X-ray | 2.8 Å | B/E=70-90 |
| 8S0E | EM | 3.8 Å | G=1-560 |
| 8RWV | EM | 6.68 Å | F=1-560 |
| 8HT7 | NMR | B=7-20 |
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