8RWV: Human OCCM DNA licensing intermediate
Human OCCM DNA licensing intermediate. Determined by electron microscopy at 6.68 Å resolution. Released 5 Feb 2025.
- Method
- Electron microscopy
- Resolution
- 6.68 Å
- Organism
- Homo sapiens
- Chains
- 14
- Atoms
- 51,862
- Mol. weight
- 967.37 kDa
- Released
- 5 Feb 2025
Explore 8RWV in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8RWV contains 286 α-helices and 203 β-strands across 12 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain 2: 30 helices, 29 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 182-185 | 4 | |
| α-helix | 192-204 | 13 | |
| α-helix | 215-222 | 8 | |
| β-strand | 229-230 | 2 | 1 |
| β-strand | 233 | 1 | 2 |
| α-helix | 234-240 | 7 | |
| α-helix | 242-244 | 3 | |
| α-helix | 255-270 | 16 | |
| α-helix | 272-276 | 5 | |
| α-helix | 281 | 1 | |
| β-strand | 282-283 | 2 | 1 |
| β-strand | 286 | 1 | 2 |
| β-strand | 305-312 | 8 | 3 |
| β-strand | 321 | 1 | 4 |
| β-strand | 325 | 1 | 5 |
| β-strand | 327 | 1 | 6 |
| β-strand | 336 | 1 | 6 |
| β-strand | 341 | 1 | 7 |
| β-strand | 346 | 1 | 7 |
| β-strand | 368 | 1 | 5 |
| β-strand | 371 | 1 | 4 |
| β-strand | 374-379 | 6 | 3 |
| α-helix | 382-384 | 3 | |
| β-strand | 393-398 | 6 | 3 |
| β-strand | 411-420 | 10 | 3 |
| β-strand | 437-439 | 3 | 3 |
| β-strand | 443-445 | 3 | 3 |
| α-helix | 453-455 | 3 | |
| α-helix | 459-467 | 9 | |
| α-helix | 489-500 | 12 | |
| β-strand | 519-522 | 4 | 8 |
| β-strand | 543 | 1 | 9 |
| β-strand | 546 | 1 | 8 |
| β-strand | 563 | 1 | 10 |
| β-strand | 568 | 1 | 10 |
| β-strand | 583 | 1 | 9 |
| β-strand | 584-587 | 4 | 8 |
| α-helix | 594-597 | 4 | |
| α-helix | 603-606 | 4 | |
| β-strand | 611-613 | 3 | 11 |
| β-strand | 616-618 | 3 | 11 |
| β-strand | 626-630 | 5 | 8 |
| α-helix | 643-646 | 4 | |
| α-helix | 654-656 | 3 | |
| β-strand | 659 | 1 | 8 |
| α-helix | 672-685 | 14 | |
| α-helix | 690-692 | 3 | |
| α-helix | 718-724 | 7 | |
| α-helix | 727-729 | 3 | |
| α-helix | 742-751 | 10 | |
| α-helix | 754-756 | 3 | |
| α-helix | 760-762 | 3 | |
| α-helix | 765-768 | 4 | |
| α-helix | 770-780 | 11 | |
| α-helix | 788-792 | 5 | |
| α-helix | 795-802 | 8 | |
| α-helix | 803-805 | 3 | |
| α-helix | 808-810 | 3 | |
| α-helix | 811-814 | 4 | |
Chain 3: 30 helices, 31 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-15 | 13 | |
| α-helix | 31-34 | 4 | |
| α-helix | 36-42 | 7 | |
| β-strand | 50 | 1 | 12 |
| α-helix | 64-67 | 4 | |
| α-helix | 72-79 | 8 | |
| α-helix | 81-87 | 7 | |
| β-strand | 103 | 1 | 12 |
| β-strand | 130-134 | 5 | 13 |
| β-strand | 138-139 | 2 | 14 |
| β-strand | 143-147 | 5 | 15 |
| β-strand | 155 | 1 | 15 |
| β-strand | 160 | 1 | 16 |
| β-strand | 171 | 1 | 16 |
| β-strand | 185-192 | 8 | 15 |
| β-strand | 195-196 | 2 | 14 |
| β-strand | 198-202 | 5 | 13 |
| α-helix | 205-207 | 3 | |
| β-strand | 216-220 | 5 | 13 |
| β-strand | 234 | 1 | 13 |
| β-strand | 235-242 | 8 | 17 |
| β-strand | 259-267 | 9 | 17 |
| α-helix | 279-289 | 11 | |
| α-helix | 295-301 | 7 | |
| α-helix | 311-314 | 4 | |
| β-strand | 342 | 1 | 18 |
| β-strand | 343-345 | 3 | 19 |
| α-helix | 351-354 | 4 | |
| α-helix | 356-359 | 4 | |
| β-strand | 368 | 1 | 20 |
| β-strand | 382-384 | 3 | 21 |
| β-strand | 391-393 | 3 | 21 |
| α-helix | 394-396 | 3 | |
| β-strand | 404-406 | 3 | 22 |
| β-strand | 408 | 1 | 20 |
| β-strand | 409 | 1 | 23 |
| α-helix | 417-421 | 5 | |
| α-helix | 422-424 | 3 | |
| β-strand | 431-435 | 5 | 24 |
| β-strand | 438-442 | 5 | 24 |
| β-strand | 446-448 | 3 | 22 |
| β-strand | 450 | 1 | 18 |
| β-strand | 451 | 1 | 23 |
| α-helix | 465-468 | 4 | |
| α-helix | 473-476 | 4 | |
| β-strand | 483-485 | 3 | 19 |
| α-helix | 491-505 | 15 | |
| α-helix | 565-569 | 5 | |
| α-helix | 572-575 | 4 | |
| β-strand | 581 | 1 | 25 |
| α-helix | 584-598 | 15 | |
| α-helix | 615-628 | 14 | |
| α-helix | 630-632 | 3 | |
| β-strand | 636 | 1 | 25 |
| α-helix | 639-641 | 3 | |
| α-helix | 646-653 | 8 | |
| α-helix | 742-751 | 10 | |
| α-helix | 765-770 | 6 | |
| α-helix | 779-781 | 3 | |
| α-helix | 784-787 | 4 | |
| α-helix | 788-790 | 3 | |
Chain 4: 26 helices, 29 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 126-128 | 3 | 26 |
| β-strand | 150-152 | 3 | 26 |
| α-helix | 159-171 | 13 | |
| α-helix | 192-195 | 4 | |
| α-helix | 197-203 | 7 | |
| β-strand | 207-211 | 5 | 27 |
| α-helix | 213-216 | 4 | |
| α-helix | 220-228 | 9 | |
| α-helix | 233-245 | 13 | |
| β-strand | 259-263 | 5 | 27 |
| β-strand | 282-286 | 5 | 28 |
| β-strand | 292 | 1 | 28 |
| β-strand | 297 | 1 | 29 |
| β-strand | 302-306 | 5 | 30 |
| β-strand | 312-315 | 4 | 30 |
| β-strand | 337-339 | 3 | 30 |
| β-strand | 348 | 1 | 29 |
| β-strand | 350-355 | 6 | 28 |
| α-helix | 361-362 | 2 | |
| α-helix | 366-368 | 3 | |
| β-strand | 369-374 | 6 | 28 |
| α-helix | 376-378 | 3 | |
| β-strand | 389-398 | 10 | 28 |
| β-strand | 412-418 | 7 | 28 |
| α-helix | 443-453 | 11 | |
| α-helix | 458-464 | 7 | |
| α-helix | 478-485 | 8 | |
| β-strand | 492 | 1 | 31 |
| α-helix | 493-495 | 3 | |
| β-strand | 497 | 1 | 31 |
| β-strand | 507-509 | 3 | 32 |
| α-helix | 522-525 | 4 | |
| β-strand | 530-533 | 4 | 33 |
| α-helix | 540-543 | 4 | |
| β-strand | 547 | 1 | 34 |
| β-strand | 558 | 1 | 34 |
| β-strand | 570-573 | 4 | 33 |
| α-helix | 581-585 | 5 | |
| α-helix | 586-588 | 3 | |
| α-helix | 590-593 | 4 | |
| β-strand | 596-600 | 5 | 35 |
| β-strand | 603-607 | 5 | 35 |
| β-strand | 612-613 | 2 | 33 |
| β-strand | 615-617 | 3 | 32 |
| α-helix | 630-633 | 4 | |
| α-helix | 638-641 | 4 | |
| β-strand | 647 | 1 | 32 |
| α-helix | 663-666 | 4 | |
| α-helix | 677-680 | 4 | |
| α-helix | 685-694 | 10 | |
| β-strand | 701 | 1 | 36 |
| α-helix | 709-716 | 8 | |
| α-helix | 731-747 | 17 | |
| β-strand | 752 | 1 | 36 |
| α-helix | 755-771 | 17 | |
Chain 6: 25 helices, 26 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 21-31 | 11 | |
| α-helix | 33-36 | 4 | |
| α-helix | 45-50 | 6 | |
| β-strand | 62-63 | 2 | 37 |
| α-helix | 65-68 | 4 | |
| α-helix | 77-81 | 5 | |
| α-helix | 87-101 | 15 | |
| β-strand | 113-114 | 2 | 37 |
| β-strand | 121 | 1 | 38 |
| β-strand | 134-136 | 3 | 39 |
| β-strand | 137 | 1 | 38 |
| β-strand | 140-143 | 4 | 39 |
| β-strand | 147-148 | 2 | 40 |
| β-strand | 151-158 | 8 | 41 |
| β-strand | 163-169 | 7 | 41 |
| β-strand | 199-200 | 2 | 41 |
| β-strand | 203-204 | 2 | 40 |
| β-strand | 205-209 | 5 | 39 |
| β-strand | 225-227 | 3 | 39 |
| β-strand | 240 | 1 | 39 |
| β-strand | 245-250 | 6 | 39 |
| β-strand | 296-300 | 5 | 39 |
| α-helix | 331-333 | 3 | |
| α-helix | 346-352 | 7 | |
| α-helix | 365-372 | 8 | |
| β-strand | 392-394 | 3 | 42 |
| α-helix | 403-412 | 10 | |
| β-strand | 418-419 | 2 | 42 |
| β-strand | 431-435 | 5 | 43 |
| β-strand | 442-446 | 5 | 43 |
| α-helix | 448-451 | 4 | |
| β-strand | 456-459 | 4 | 42 |
| α-helix | 468-471 | 4 | |
| β-strand | 481-483 | 3 | 44 |
| β-strand | 486 | 1 | 45 |
| β-strand | 489 | 1 | 45 |
| β-strand | 492-494 | 3 | 44 |
| β-strand | 498-502 | 5 | 42 |
| α-helix | 524-529 | 6 | |
| α-helix | 544-557 | 14 | |
| α-helix | 569-572 | 4 | |
| α-helix | 574-576 | 3 | |
| α-helix | 591-594 | 4 | |
| α-helix | 598-605 | 8 | |
| α-helix | 618-631 | 14 | |
| α-helix | 642-653 | 12 | |
| α-helix | 721-731 | 11 | |
| α-helix | 751-753 | 3 | |
| α-helix | 754-757 | 4 | |
| α-helix | 773-776 | 4 | |
| α-helix | 778-781 | 4 | |
Chain 7: 26 helices, 31 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 21-23 | 3 | |
| α-helix | 32-34 | 3 | |
| α-helix | 36-41 | 6 | |
| β-strand | 47-50 | 4 | 46 |
| α-helix | 53-56 | 4 | |
| α-helix | 60-68 | 9 | |
| α-helix | 77-83 | 7 | |
| α-helix | 101-113 | 13 | |
| α-helix | 122-124 | 3 | |
| β-strand | 135-138 | 4 | 46 |
| β-strand | 147 | 1 | 47 |
| α-helix | 154-156 | 3 | |
| β-strand | 162-163 | 2 | 47 |
| β-strand | 166-170 | 5 | 47 |
| β-strand | 174-177 | 4 | 48 |
| β-strand | 179-184 | 6 | 49 |
| β-strand | 189-194 | 6 | 49 |
| α-helix | 211-214 | 4 | |
| β-strand | 220-223 | 4 | 49 |
| β-strand | 229-232 | 4 | 48 |
| β-strand | 235-238 | 4 | 47 |
| β-strand | 253-254 | 2 | 47 |
| β-strand | 255 | 1 | 50 |
| β-strand | 270-276 | 7 | 47 |
| β-strand | 279 | 1 | 51 |
| β-strand | 296 | 1 | 51 |
| β-strand | 298 | 1 | 50 |
| β-strand | 299-306 | 8 | 47 |
| α-helix | 335-339 | 5 | |
| α-helix | 348-355 | 8 | |
| β-strand | 377-380 | 4 | 52 |
| α-helix | 387-397 | 11 | |
| β-strand | 417-419 | 3 | 53 |
| β-strand | 428-430 | 3 | 53 |
| β-strand | 440-445 | 6 | 52 |
| α-helix | 452-456 | 5 | |
| α-helix | 458-461 | 4 | |
| β-strand | 467-470 | 4 | 54 |
| β-strand | 475-478 | 4 | 54 |
| β-strand | 482-488 | 7 | 52 |
| β-strand | 517-520 | 4 | 52 |
| α-helix | 527-536 | 10 | |
| α-helix | 538-541 | 4 | |
| α-helix | 559-563 | 5 | |
| β-strand | 572 | 1 | 55 |
| α-helix | 578-588 | 11 | |
| α-helix | 590-593 | 4 | |
| α-helix | 606-611 | 6 | |
| α-helix | 613-617 | 5 | |
| β-strand | 624 | 1 | 55 |
| α-helix | 628-643 | 16 | |
| α-helix | 659-669 | 11 | |
| β-strand | 674-676 | 3 | 56 |
| α-helix | 681-687 | 7 | |
| α-helix | 691-702 | 12 | |
| β-strand | 707-708 | 2 | 56 |
| β-strand | 715-718 | 4 | 56 |
Chain A: 20 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 488-495 | 8 | |
| α-helix | 508-522 | 15 | |
| β-strand | 528 | 1 | 57 |
| β-strand | 531 | 1 | 58 |
| α-helix | 543-555 | 13 | |
| α-helix | 579-587 | 9 | |
| α-helix | 596-605 | 10 | |
| β-strand | 617-620 | 4 | 58 |
| α-helix | 623-625 | 3 | |
| α-helix | 634-637 | 4 | |
| β-strand | 648 | 1 | 57 |
| β-strand | 649-652 | 4 | 58 |
| α-helix | 665-669 | 5 | |
| α-helix | 679-681 | 3 | |
| α-helix | 683-693 | 11 | |
| α-helix | 702-715 | 14 | |
| α-helix | 720-732 | 13 | |
| α-helix | 749-756 | 8 | |
| α-helix | 764-768 | 5 | |
| α-helix | 773-784 | 12 | |
| α-helix | 795-809 | 15 | |
| α-helix | 813-815 | 3 | |
| α-helix | 819-828 | 10 | |
| β-strand | 832-833 | 2 | 59 |
| α-helix | 843-845 | 3 | |
| β-strand | 846-847 | 2 | 59 |
| α-helix | 853-856 | 4 | |
Chain B: 15 helices, 9 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 284-295 | 12 | |
| α-helix | 298-300 | 3 | |
| α-helix | 302-305 | 4 | |
| β-strand | 311-316 | 6 | 60 |
| α-helix | 320-330 | 11 | |
| β-strand | 336-340 | 5 | 60 |
| α-helix | 349-352 | 4 | |
| α-helix | 369-381 | 13 | |
| β-strand | 388-393 | 6 | 60 |
| α-helix | 403-412 | 10 | |
| β-strand | 418-423 | 6 | 60 |
| α-helix | 429-431 | 3 | |
| α-helix | 435-441 | 7 | |
| β-strand | 445-449 | 5 | 60 |
| α-helix | 474-482 | 9 | |
| α-helix | 486-501 | 16 | |
| β-strand | 511 | 1 | 61 |
| α-helix | 514-522 | 9 | |
| α-helix | 530-534 | 5 | |
| α-helix | 537-540 | 4 | |
| β-strand | 546 | 1 | 62 |
| β-strand | 557 | 1 | 61 |
| β-strand | 558 | 1 | 62 |
| α-helix | 563-567 | 5 | |
Chain C: 37 helices, 9 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 11-13 | 3 | 60 |
| α-helix | 27-29 | 3 | |
| α-helix | 37-45 | 9 | |
| α-helix | 49-65 | 17 | |
| α-helix | 67-74 | 8 | |
| α-helix | 76-79 | 4 | |
| α-helix | 82-87 | 6 | |
| β-strand | 100-105 | 6 | 63 |
| α-helix | 114-128 | 15 | |
| β-strand | 134 | 1 | 63 |
| α-helix | 145-157 | 13 | |
| α-helix | 182-194 | 13 | |
| α-helix | 212-214 | 3 | |
| β-strand | 215-219 | 5 | 63 |
| α-helix | 241-243 | 3 | |
| β-strand | 246-250 | 5 | 63 |
| α-helix | 256-258 | 3 | |
| α-helix | 259-262 | 4 | |
| α-helix | 268-270 | 3 | |
| β-strand | 271-276 | 6 | 63 |
| α-helix | 285-288 | 4 | |
| α-helix | 304-316 | 13 | |
| α-helix | 322-333 | 12 | |
| α-helix | 335-338 | 4 | |
| α-helix | 340-344 | 5 | |
| α-helix | 352-355 | 4 | |
| α-helix | 362-367 | 6 | |
| α-helix | 370-378 | 9 | |
| α-helix | 381-383 | 3 | |
| α-helix | 392-412 | 21 | |
| α-helix | 414-422 | 9 | |
| α-helix | 423-425 | 3 | |
| α-helix | 437-440 | 4 | |
| α-helix | 460-462 | 3 | |
| α-helix | 472-479 | 8 | |
| α-helix | 492-503 | 12 | |
| α-helix | 547-561 | 15 | |
| α-helix | 595-604 | 10 | |
| α-helix | 607-610 | 4 | |
| α-helix | 621-623 | 3 | |
| α-helix | 628-635 | 8 | |
| β-strand | 642-644 | 3 | 64 |
| α-helix | 646-652 | 7 | |
| α-helix | 670-689 | 20 | |
| β-strand | 693-696 | 4 | 64 |
| β-strand | 702-705 | 4 | 64 |
4 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| DNA replication licensing factor MCM2 | 2 | protein | 947 | Homo sapiens | P49736 (AlphaFold model) |
| Isoform 2 of DNA replication licensing factor MCM3 | 3 | protein | 853 | Homo sapiens | P25205 (AlphaFold model) |
| DNA replication licensing factor MCM4 | 4 | protein | 883 | Homo sapiens | P33991 (AlphaFold model) |
| DNA replication licensing factor MCM6 | 6 | protein | 821 | Homo sapiens | Q14566 (AlphaFold model) |
| DNA replication licensing factor MCM7 | 7 | protein | 719 | Homo sapiens | P33993 |
| Origin recognition complex subunit 1 | A | protein | 961 | Homo sapiens | Q13415 |
| Origin recognition complex subunit 2 | B | protein | 577 | Homo sapiens | Q13416 |
| Isoform 2 of Origin recognition complex subunit 3 | C | protein | 712 | Homo sapiens | Q9UBD5 |
| Origin recognition complex subunit 4 | D | protein | 436 | Homo sapiens | O43929 |
| Origin recognition complex subunit 5 | E | protein | 435 | Homo sapiens | O43913 |
| Cell division control protein 6 homolog | F | protein | 560 | Homo sapiens | Q99741 |
| DNA replication factor Cdt1 | G | protein | 410 | Homo sapiens | Q9H211 |
2 more molecules are not listed.
Sequence of entity 1 (2), FASTA
>8RWV_1 DNA replication licensing factor MCM2 (chains 2)
MSAWSHPQFEKGGGSGGGSGGSAWSHPQFEKENLYFQGAGSATMAESSESFTMASSPAQR
RRGNDPLTSSPGRSSRRTDALTSSPGRDLPPFEDESEGLLGTEGPLEEEEDGEELIGDGM
ERDYRAIPELDAYEAEGLALDDEDVEELTASQREAAERAMRQRDREAGRGLGRMRRGLLY
DSDEEDEERPARKRRQVERATEDGEEDEEMIESIENLEDLKGHSVREWVSMAGPRLEIHH
RFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQ
IFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSCTG
VLPQLSMVKYNCNKCNFVLGPFCQSQNQEVKPGSCPECQSAGPFEVNMEETIYQNYQRIR
IQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNTANGFPVFAT
VILANHVAKKDNKVAVGELTDEDVKMITSLSKDQQIGEKIFASIAPSIYGHEDIKRGLAL
ALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLT
AYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIV
TSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDILCVVRDTVDPVQDEMLAR
FVVGSHVRHHPSNKEEEGLANGSAAEPAMPNTYGVEPLPQEVLKKYIIYAKERVHPKLNQ
MDQDKVAKMYSDLRKESMATGSIPITVRHIESMIRMAEAHARIHLRDYVIEDDVNMAIRV
MLESFIDTQKFSVMRSMRKTFARYLSFRRDNNELLLFILKQLVAEQVTYQRNRFGAQQDT
IEVPEKDLVDKARQINIHNLSAFYDSELFRMNKFSHDLKRKMILQQF
Sequence of entity 2 (3), FASTA
>8RWV_2 Isoform 2 of DNA replication licensing factor MCM3 (chains 3)
MLPRSPPLPRGNLWWREEFGSFRAGVESSWEPPRDFGGGSSLAAGMAGTVVLDDVELREA
QRDYLDFLDDEEDQGIYQSKVRELISDNQYRLIVNVNDLRRKNEKRANRLLNNAFEELVA
FQRALKDFVASIDATYAKQYEEFYVGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCS
LVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEENNPLETEYGLSVYKD
HQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLPGKKGGYTSGT
FRTVLIACNVKQMSKDAQPSFSAEDIAKIKKFSKTRSKDIFDQLAKSLAPSIHGHDYVKK
AILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSG
VGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAK
AGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDR
EISDHVLRMHRYRAPGEQDGDAMPLGSAVDILATDDPNFSQEDQQDTQIYEKHDNLLHGT
KKKKEKMVSAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQDSMSSDTARTSPVTA
RTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKRSEDESETE
DEEEKSQEDQEQKRKRRKTRQPDAKDGDSYDPYDFSDTEEEMPQVHTPKTADSQETKESQ
KVELSESRLKAFKVALLDVFREAHAQSIGMNRLTESINRDSEEPFSSVEIQAALSKMQDD
NQVMVSEGIIFLI
Sequence of entity 3 (4), FASTA
>8RWV_3 DNA replication licensing factor MCM4 (chains 4)
MHHHHHHHHENLYFQGSSATMSSPASTPSRRGSRRGRATPAQTPRSEDARSSPSQRRRGE
DSTSTGELQPMPTSPGVDLQSPAAQDVLFSSPPQMHSSAIPLDFDVSSPLTYGTPSSRVE
GTPRSGVRGTPVRQRPDLGSAQKGLQVDLQSDGAAAEDIVASEQSLGQKLVIWGTDVNVA
ACKENFQRFLQRFIDPLAKEEENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDK
NLYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILEHQIQVRPFNALKTKNMRNLNPEDID
QLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEMDRGRIAEPSVCGRCHTTHSMALI
HNRSLFSDKQMIKLQESPEDMPAGQTPHTVILFAHNDLVDKVQPGDRVNVTGIYRAVPIR
VNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYE
RLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLL
QYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMN
ESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTL
LSRFDLIFLLLDPQDEAYDRRLAHHLVALYYQSEEQAEEELLDMAVLKDYIAYAHSTIMP
RLSEEASQALIEAYVDMRKIGSSRGMVSAYPRQLESLIRLAEAHAKVRLSNKVEAIDVEE
AKRLHREALKQSATDPRTGIVDISILTTGMSATSRKRKEELAEALKKLILSKGKTPALKY
QQLFEDIRGQSDIAITKDMFEEALRALADDDFLTVTGKTVRLL
Sequence of entity 4 (6), FASTA
>8RWV_4 DNA replication licensing factor MCM6 (chains 6)
MDLAAAAEPGAGSQHLEVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNT
LVVSFVDLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRKEIPLAKDFYVAFQDLPTR
HKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQFKYTQPNIC
RNPVCANRRRFLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGD
KCDFTGTLIVVPDVSKLSTPGARAETNSRVSGVDGYETEGIRGLRALGVRDLSYRLVFLA
CCVAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHG
NDEVKRGVLLMLFGGVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVEEFSPRAVYTS
GKASSAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQ
TISITKAGVKATLNARTSILAAANPISGHYDRSKSLKQNINLSAPIMSRFDLFFILVDEC
NEVTDYAIARRIVDLHSRIEESIDRVYSLDDIRRYLLFARQFKPKISKESEDFIVEQYKH
LRQRDGSGVTKSSWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKSIIRVE
TPDVNLDQEEEIQMEVDEGAGGINGHADSPAPVNGINGYNEDINQESAPKASLRLGFSEY
CRISNLIVLHLRKVEEEEDESALKRSELVNWYLKEIESEIDSEEELINKKRIIEKVIHRL
THYDHVLIELTQAGLKGSTEGSESYEEDPYLVVNPNYLLED
Sequence of entity 5 (7), FASTA
>8RWV_5 DNA replication licensing factor MCM7 (chains 7)
MALKDYALEKEKVKKFLQEFYQDDELGKKQFKYGNQLVRLAHREQVALYVDLDDVAEDDP
ELVDSICENARRYAKLFADAVQELLPQYKEREVVNKDVLDVYIEHRLMMEQRSRDPGMVR
SPQNQYPAELMRRFELYFQGPSSNKPRVIREVRADSVGKLVTVRGIVTRVSEVKPKMVVA
TYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEH
SDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSETYLEA
HRIVKMNKSEDDESGAGELTREELRQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVG
GVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLR
DSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNA
RCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYV
HQHSRQPPSQFEPLDMKLMRRYIAMCREKQPMVPESLADYITAAYVEMRREAWASKDATY
TSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSKDSLLGDKGQTARTQRPADV
IFATVRELVSGGRSVRFSEAEQRCVSRGFTPAQFQAALDEYEELNVWQVNASRTRITFV
Sequence of entity 6 (A), FASTA
>8RWV_6 Origin recognition complex subunit 1 (chains A)
MGSLQDSEVNQEAKPEVKPEVKPETHINLKVSDGSSEIFFKIKKTTPLRRLMEAFAKRQG
KEMDSLTFLYDGIEIQADQAPEDLDMEDNDIIEAHREQIGGAHYPTRLKTRKTYSWVGRP
LLDRKLHYQTYREMCVKTEGCSTEIHIQIGQFVLIEGDDDENPYVAKLLELFEDDSDPPP
KKRARVQWFVRFCEVPACKRHLLGRKPGAQEIFWYDYPACDSNINAETIIGLVRVIPLAP
KDVVPTNLKNEKTLFVKLSWNEKKFRPLSSELFAELNKPQESAAKCQKPVRAKSKSAESP
SWTPAEHVAKRIESRHSASKSRQTPTHPLTPRARKRLELGNLGNPQMSQQTSCASLDSPG
RIKRKVAFSEITSPSKRSQPDKLQTLSPALKAPEKTRETGLSYTEDDKKASPEHRIILRT
RIAASKTIDIREERTLTPISGGQRSSVVPSVILKPENIKKRDAKEAKAQNEATSTPHRIR
RKSSVLTMNRIRQQLRFLGNSKSDQEEKEILPAAEISDSSSDEEEASTPPLPRRAPRTVS
RNLRSSLKSSLHTLTKVPKKSLKPRTPRCAAPQIRSRSLAAQEPASVLEEARLRLHVSAV
PESLPCREQEFQDIYNFVESKLLDHTGGCMYISGVPGTGKTATVHEVIRCLQQAAQANDV
PPFQYIEVNGMKLTEPHQVYVQILQKLTGQKATANHAAELLAKQFCTRGSPQETTVLLVD
ELDLLWTHKQDIMYNLFDWPTHKEARLVVLAIANTMDLPERIMMNRVSSRLGLTRMCFQP
YTYSQLQQILRSRLKHLKAFEDDAIQLVARKVAALSGDARRCLDICRRATEICEFSQQKP
DSPGLVTIAHSMEAVDEMFSSSYITAIKNSSVLEQSFLRAILAEFRRSGLEEATFQQIYS
QHVALCRMEGLPYPTMSETMAVCSHLGSCRLLLVEPSRNDLLLRVRLNVSQDDVLYALKD
E
Sequence of entity 7 (B), FASTA
>8RWV_7 Origin recognition complex subunit 2 (chains B)
MSKPELKEDKMLEVHFVGDDDVLNHILDREGGAKLKKERAQLLVNPKKIIKKPEYDLEED
DQEVLKDQNYVEIMGRDVQESLKNGSATGGGNKVYSFQNRKHSEKMAKLASELAKTPQKS
VSFSLKNDPEITINVPQSSKGHSASDKVQPKNNDKSEFLSTAPRSLRKRLIVPRSHSDSE
SEYSASNSEDDEGVAQEHEEDTNAVIFSQKIQAQNRVVSAPVGKETPSKRMKRDKTSDLV
EEYFEAHSSSKVLTSDRTLQKLKRAKLDQQTLRNLLSKVSPSFSAELKQLNQQYEKLFHK
WMLQLHLGFNIVLYGLGSKRDLLERFRTTMLQDSIHVVINGFFPGISVKSVLNSITEEVL
DHMGTFRSILDQLDWIVNKFKEDSSLELFLLIHNLDSQMLRGEKSQQIIGQLSSLHNIYL
IASIDHLNAPLMWDHAKQSLFNWLWYETTTYSPYTEETSYENSLLVKQSGSLPLSSLTHV
LRSLTPNARGIFRLLIKYQLDNQDNPSYIGLSFQDFYQQCREAFLVNSDLTLRAQLTEFR
DHKLIRTKKGTDGVEYLLIPVDNGTLTDFLEKEEEEA
Sequence of entity 8 (C), FASTA
>8RWV_8 Isoform 2 of Origin recognition complex subunit 3 (chains C)
MATSSMSKGCFVFKPNSKKRKISLPIEDYFNKGKNEPEDSKLRFETYQLIWQQMKSENER
LQEELNKNLFDNLIEFLQKSHSGFQKNSRDLGGQIKLREIPTAALVLGVNVTDHDLTFGS
LTEALQNNVTPYVVSLQAKDCPDMKHFLQKLISQLMDCCVDIKSKEEESVHVTQRKTHYS
MDSLSSWYMTVTQKTDPKMLSKKRTTSSQWQSPPVVVILKDMESFATKVLQDFIIISSQH
LHEFPLILIFGIATSPIIIHRLLPHAVSSLLCIELFQSLSCKEHLTTVLDKLLLTTQFPF
KINEKVLQVLTNIFLYHDFSVQNFIKGLQLSLLEHFYSQPLSVLCCNLPEAKRRINFLSN
NQCENIRRLPSFRRYVEKQASEKQVALLTNERYLKEETQLLLENLHVYHMNYFLVLRCLH
KFTSSLPKYPLGRQIRELYCTCLEKNIWDSEEYASVLQLLRMLAKDELMTILEKCFKVFK
SYCENHLGSTAKRIEEFLAQFQSLDAETKEEEDASGSQPKGLQKTDLYHLQKSLLEMKEL
RRSKKQTKFEVLRENVVNFIDCLVREYLLPPETQPLHEVVYFSAAHALREHLNAAPRIAL
HTALNNPYYYLKNEALKSEEGCIPNIAPDICIAYKLHLECSRLINLVDWSEAFATVVTAA
EKMDANSATSEEMNEIIHARFIRAVSELELLGFIKPTKQKTDHVARLTWGGC
Sequence of entity 9 (D), FASTA
>8RWV_9 Origin recognition complex subunit 4 (chains D)
MSSRKSKSNSLIHTECLSQVQRILRERFCRQSPHSNLFGVQVQYKHLSELLKRTALHGES
NSVLIIGPRGSGKTMLINHALKELMEIEEVSENVLQVHLNGLLQINDKIALKEITRQLNL
ENVVGDKVFGSFAENLSFLLEALKKGDRTSSCPVIFILDEFDLFAHHKNQTLLYNLFDIS
QSAQTPIAVIGLTCRLDILELLEKRVKSRFSHRQIHLMNSFGFPQYVKIFKEQLSLPAEF
PDKVFAEKWNENVQYLSEDRSVQEVLQKHFNISKNLRSLHMLLMLALNRVTASHPFMTAV
DLMEASQLCSMDSKANIVHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFVQRK
AHSVYNFEKPVVMKAFEHLQQLELIKPMERTSGNSQREYQLMKLLLDNTQIMNALQKYPN
CPTDVRQWATSSLSWL
Sequence of entity 10 (E), FASTA
>8RWV_10 Origin recognition complex subunit 5 (chains E)
MPHLENVVLCRESQVSILQSLFGERHHFSFPSIFIYGHTASGKTYVTQTLLKTLELPHVF
VNCVECFTLRLLLEQILNKLNHLSSSEDGCSTEITCETFNDFVRLFKQVTTAENLKDQTV
YIVLDKAEYLRDMEANLLPGFLRLQELADRNVTVLFLSEIVWEKFRPNTGCFEPFVLYFP
DYSIGNLQKILSHDHPPEYSADFYAAYINILLGVFYTVCRDLKELRHLAVLNFPKYCEPV
VKGEASERDTRKLWRNIEPHLKKAMQTVYLREISSSQWEKLQKDDTDPGQLKGLSAHTHV
ELPYYSKFILIAAYLASYNPARTDKRFFLKHHGKIKKTNFLKKHEKTSNHLLGPKPFPLD
RLLAILYSIVDSRVAPTANIFSQITSLVTLQLLTLVGHDDQLDGPKYKCTVSLDFIRAIA
RTVNFDIIKYLYDFL
Sequence of entity 11 (F), FASTA
>8RWV_11 Cell division control protein 6 homolog (chains F)
MPQTRSQAQATISFPKRKLSRALNKAKNSSDAKLEPTNVQTVTCSPRVKALPLSPRKRLG
DDNLCNTPHLPPCSPPKQGKKENGPPHSHTLKGRRLVFDNQLTIKSPSKRELAKVHQNKI
LSSVRKSQEITTNSEQRCPLKKESACVRLFKQEGTCYQQAKLVLNTAVPDRLPAREREMD
VIRNFLREHICGKKAGSLYLSGAPGTGKTACLSRILQDLKKELKGFKTIMLNCMSLRTAQ
AVFPAIAQEICQEEVSRPAGKDMMRKLEKHMTAEKGPMIVLVLDEMDQLDSKGQDVLYTL
FEWPWLSNSHLVLIGIANTLDLTDRILPRLQAREKCKPQLLNFPPYTRNQIVTILQDRLN
QVSRDQVLDNAAVQFCARKVSAVSGDVRKALDVCRRAIEIVESDVKSQTILKPLSECKSP
SEPLIPKRVGLIHISQVISEIDGNRMTLSQEGAQDSFPLQQKILVCSLMLLIRQLKIKEV
TLGKLYEAYSKVCRKQQVAAVDQSECLSLSGLLEARGILGLKRNKETRLTKVFFKIEEKE
IEHALKDKALIGNILATGLP
Sequence of entity 12 (G), FASTA
>8RWV_12 DNA replication factor Cdt1 (chains G)
MGSSHHHHHHSSGLEVLFQGPRPEEPCGEKAPAYQRFHALAQPGLPGLVLPYKYQVLAEM
FRSMDTIVGMLHNRSETPTFAKVQRGVQDMMRRRFEECNVGQIKTVYPASYRFRQERSVP
TFKDGTRRSDYQLTIEPLLEQEADGAAPQLTASRLLQRRQIFSQKLVEHVKEHHKAFLAS
LSPAMVVPEDQLTRWHPRFNVDEVPDIEPAALPQPPATEKLTTAQEVLARARNLISPRME
KALSQLALRSAAPSSPGSPRPALPATPPATPPAASPSALKGVSQDLLERIRAKEAQKQLA
QMTRCPEQEQRLQRLERLPELARVLRSVFVSERKPALSMEVACARMVGSCCTIMSPGEME
KHLLLLSELLPDWLSLHRIRTDTYVKLDKAADLAHITARLAHQTRAEEGL
Primary citation
Reconstitution of human DNA licensing and the structural and functional analysis of key intermediates. Wells, J.N., Edwardes, L.V., Leber, V. et al. Nat Commun (2025) 16:478-478. DOI 10.1038/s41467-024-55772-z · PubMed
Other PDB entries of the same protein (UniProt P49736 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 6YA7 1.67 Å, Cdc7-Dbf4 bound to an Mcm2-S40 derived bivalent substrate
- 7CIZ 1.8 Å, Crystal structure of DNAJC9 HBD helix2 in complex with H3.3-H4 dimer and MCM2 HBD
- 5BNX 2.31 Å, Crystal structure of Human MCM2 HBD and ASF1b chaperoning a histone H3.3-H4 dimer
- 5JA4 2.42 Å, Crystal structure of human TONSL and MCM2 HBDs binding to a histone H3-H4 tetramer
- 7CJ0 2.5 Å, Crystal structure of DNAJC9 HBD in complex with H3.3-H4 dimer and MCM2 HBD
- 7W1Y 2.59 Å, Human MCM double hexamer bound to natural DNA duplex (polyAT/polyTA)
- 9E2Z 2.6 Å, Cryo-EM structure of human CMG helicase stalled at G4-containing DNA template
- 5BNV 2.79 Å, Crystal structure of Human MCM2 HBD chaperoning a histone H3-H4 tetramer
- 7PLO 2.8 Å, H. sapiens replisome-CUL2/LRR1 complex
- 8W0F 2.8 Å, Cryo-EM structure of a human MCM2-7 double hexamer on dsDNA
- 4UUZ 2.9 Å, MCM2-histone complex
- 5BO0 2.91 Å, Crystal structure of Human MCM2 HBD and ASF1b chaperoning a histone H3.2-H4 dimer
Browse structure collections
About this viewer
MolViewer shows 8RWV directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.