Histone H2B type 1-M (H2BC14) is a 126-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q99879.
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The mean pLDDT of this model is 87.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 68% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 10YE | EM | 2.5 Å | D/H=33-125 |
| 9D3P | EM | 2.5 Å | D/H=32-126 |
| 9D3K | EM | 2.7 Å | D=35-124, H=36-125 |
| 9D3L | EM | 2.8 Å | D/H=35-124 |
| 9D3Q | EM | 2.8 Å | D/H=33-126 |
| 9D3T | EM | 2.8 Å | D/H=36-124 |
| 10YH | EM | 2.9 Å | D/H=33-125 |
| 10YI | EM | 2.9 Å | D/H=33-125 |
| 9D3M | EM | 2.9 Å | D/H=32-124 |
| 9D3N | EM | 3.0 Å | D/H=37-125 |
| 9D3O | EM | 3.0 Å | D/H=30-124 |
| 9D3S | EM | 3.1 Å | D/H=32-125 |
| 10YG | EM | 3.4 Å | D/H=33-125 |
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