Retinoic acid receptor responder protein 2 (RARRES2) is a 163-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q99969.
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The mean pLDDT of this model is 86.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 66% |
| 70 to 90 | Confident: backbone generally right | 15% |
| 50 to 70 | Low: treat with caution | 17% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Also acts as a ligand for CMKLR2. Can also bind to C-C chemokine receptor-like 2 (CCRL2), but with a lower affinity than it does to CMKLR1 or CMKLR2 (PubMed:27716822). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a pro-inflammatory adipokine, causing an increase in secretion of pro-inflammatory and prodiabetic adipokines, which further…
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7YKD | EM | 2.81 Å | L=149-157 |
| 8JJP | EM | 2.9 Å | L=149-157 |
| 8SG1 | EM | 2.94 Å | L=149-157 |
| 8ZJG | EM | 3.18 Å | L=21-157 |
| 9UYI | EM | 3.2 Å | L=20-157 |
| 8XGM | EM | 3.29 Å | D=21-157 |
| 9UYH | EM | 3.3 Å | L=20-157 |
| 9UYJ | EM | 3.3 Å | L=20-157 |
| 9UYL | EM | 3.3 Å | L=20-157 |
| 9L3W | EM | 3.5 Å | L=21-157 |
| 9UYM | EM | 3.5 Å | L=20-157 |
| 9L3Y | EM | 3.6 Å | L=21-157 |
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