FYVE and coiled-coil domain-containing protein 1 (FYCO1) is a 1478-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9BQS8.
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The mean pLDDT of this model is 71.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 14% |
| 70 to 90 | Confident: backbone generally right | 55% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 18% |
What pLDDT means and how to read it
May mediate microtubule plus end-directed vesicle transport
Can form homodimers. Interacts (via C-terminus) with MAP1LC3B. Interacts with RAB7A; the interaction with RAB7A induces FYCO1 recruitment to late endosomal/lysosomal compartments. Interacts with MAP1LC3B (By similarity)
Cytoplasmic vesicle, autophagosome, Endosome, Lysosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7BQI | X-ray | 1.3 Å | A=1-178 |
| 5D94 | X-ray | 1.53 Å | B=1276-1288 |
| 5CX3 | X-ray | 2.3 Å | E/F/G/H=1273-1298 |
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