DNA replication complex GINS protein SLD5 (GINS4) is a 223-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9BRT9.
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The mean pLDDT of this model is 90.4 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 81% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653, PubMed:28414293). GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232)
Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS1. GINS complex interacts with DNA primase in vitro (PubMed:17170760, PubMed:17417653, PubMed:17545466, PubMed:17557111, PubMed:17652513, PubMed:28414293, PubMed:32453425). Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by…
Nucleus, Chromosome, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2E9X | X-ray | 2.3 Å | D/H=1-223 |
| 2Q9Q | X-ray | 2.36 Å | B/F=1-223 |
| 9E2Z | EM | 2.6 Å | D=1-223 |
| 7PLO | EM | 2.8 Å | G=1-223 |
| 2EHO | X-ray | 3.0 Å | A/E/I=11-213 |
| 7PFO | EM | 3.2 Å | G=1-223 |
| 6XTX | EM | 3.29 Å | D=1-223 |
| 8B9D | EM | 3.4 Å | G=1-223 |
| 8OK2 | EM | 4.1 Å | D=1-223 |
| 6XTY | EM | 6.77 Å | D=1-223 |
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