DNA-directed RNA polymerase III subunit RPC3 (POLR3C) is a 534-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9BUI4.
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The mean pLDDT of this model is 89.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 73% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:20413673, PubMed:33558764, PubMed:33558766, PubMed:34675218, PubMed:35637192). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci (PubMed:20413673, PubMed:33558764, PubMed:33558766, PubMed:35637192). Part of POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer, coordinates the dynamics of Pol III stalk and clamp modules during the transition from apo to elongation state (PubMed:33558764, PubMed:33558766). Pol III plays a key…
Component of the RNA polymerase III complex consisting of 17 subunits: a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2XUB | X-ray | 2.8 Å | A=1-534 |
| 7AE1 | EM | 2.8 Å | O=1-534 |
| 9K39 | EM | 2.8 Å | O=1-534 |
| 7D58 | EM | 2.9 Å | O=1-534 |
| 9K36 | EM | 2.9 Å | O=1-534 |
| 2XV4 | X-ray | 2.95 Å | S=1-534 |
| 9K2G | EM | 3.0 Å | O=1-534 |
| 9K3U | EM | 3.0 Å | O=1-534 |
| 7AE3 | EM | 3.1 Å | O=1-534 |
| 7D59 | EM | 3.1 Å | O=1-534 |
| 9K38 | EM | 3.1 Å | O=1-534 |
| 9FSO | EM | 3.28 Å | C=1-534 |
| 7A6H | EM | 3.3 Å | O=1-534 |
| 9LXN | EM | 3.3 Å | O=1-534 |
| 7DU2 | EM | 3.35 Å | O=1-534 |
| 9FSP | EM | 3.39 Å | C=1-534 |
| 7AEA | EM | 3.4 Å | O=1-534 |
| 8IUH | EM | 3.4 Å | O=1-534 |
| 7DN3 | EM | 3.5 Å | O=1-534 |
| 9K3V | EM | 3.5 Å | O=1-534 |
Showing 20 of 32 experimental structures (best resolution first).
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