Programmed cell death protein 10 (PDCD10) is a 212-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9BUL8.
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The mean pLDDT of this model is 90.8 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 83% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity (PubMed:27807006). Important for cell migration, and for normal structure and assembly of the Golgi complex (PubMed:27807006). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation…
Homodimer (PubMed:20489202). Interacts (via C-terminus) with CCM2 (PubMed:17360971, PubMed:20489202). Interacts (via C-terminus) with PXN (PubMed:20489202). Interacts (via N-terminus) with STK25 (PubMed:17360971, PubMed:20332113). Interacts (via N-terminus) with STK26 (PubMed:17360971, PubMed:20332113, PubMed:27807006). Interacts (via N-terminus) with STK24 (PubMed:20332113, PubMed:27807006).…
Cytoplasm, Golgi apparatus membrane, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4GEH | X-ray | 1.95 Å | A/C=9-212 |
| 3AJM | X-ray | 2.3 Å | A/B=8-212 |
| 3W8I | X-ray | 2.4 Å | A=8-212 |
| 3W8H | X-ray | 2.43 Å | A=8-212 |
| 3L8I | X-ray | 2.5 Å | A/B/C/D=1-212 |
| 3RQG | X-ray | 2.5 Å | A/B/C/D=1-212 |
| 3RQF | X-ray | 2.7 Å | A/B/C/D=1-212 |
| 3RQE | X-ray | 2.8 Å | A/B/C/D=1-212 |
| 4TVQ | X-ray | 2.8 Å | A/B/C/D=1-212 |
| 3L8J | X-ray | 3.05 Å | A=14-212 |
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