3W8H: CCM3

Crystal structure of CCM3 in complex with the C-terminal regulatory domain of STK25. Determined by X-ray diffraction at 2.43 Å resolution. Released 3 Jul 2013.

Method: X-ray diffraction
Resolution: 2.43 Å
Organism: Homo sapiens
Chains: 2
Atoms: 2,206
Mol. weight: 34.18 kDa
Released: 3 Jul 2013

Explore 3W8H in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3W8H contains 17 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 12 helices, 0 β-strands

Element	Residues	Length
α-helix	20	1
α-helix	21-26	6
α-helix	27-32	6
α-helix	38-54	17
α-helix	58-69	12
α-helix	76-83	8
α-helix	89-91	3
α-helix	98-114	17
α-helix	117-120	4
α-helix	124-148	25
α-helix	159-184	26
α-helix	187-209	23

Chain B: 5 helices, 0 β-strands

Element	Residues	Length
α-helix	357	1
α-helix	358-362	5
α-helix	363-374	12
α-helix	381-396	16
α-helix	400-414	15

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Programmed cell death protein 10	A	protein	213	Homo sapiens	Q9BUL8 (AlphaFold model)
Serine/threonine-protein kinase 25	B	protein	78	Homo sapiens	O00506 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>3W8H_1 Programmed cell death protein 10 (chains A)
MKNEAETTSMVSMPLYAVMYPVFNELERVNLSAAQTLRAAFIKAEKENPGLTQDIIMKIL
EKKSVEVNFTESLLRMAADDVEEYMIERPEPEFQDLNEKARALKQILSKIPDEINDRVRF
LQTIKDIASAIKELLDTVNNVFKKYQYQNRRALEHQKKEFVKYSKSFSDTLKTYFKDGKA
INVFVSANRLIHQTNLILQTFKTVALEHHHHHH

Sequence of entity 2 (B), FASTA

>3W8H_2 Serine/threonine-protein kinase 25 (chains B)
GPGSEFSQCLSTLVRPVFGELKEKHKQSGGSVGALEELENAFSLAEESCPGISDKLMVHL
VERVQRFSHNRNHLTSTR

Primary citation

Structural Basis for the Unique Heterodimeric Assembly between Cerebral Cavernous Malformation 3 and Germinal Center Kinase III. Xu, X., Wang, X., Zhang, Y. et al. Structure (2013) 21:1059-1066. DOI 10.1016/j.str.2013.04.007 · PubMed

Other PDB entries of the same protein (UniProt Q9BUL8 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4GEH 1.95 Å, Crystal structure of MST4 dimerization domain complex with PDCD10
3AJM 2.3 Å, Crystal structure of programmed cell death 10 in complex with inositol…
3W8I 2.4 Å, Crystal structure of CCM3 in complex with the C-terminal regulatory domain of MST4
3L8I 2.5 Å, Crystal structure of CCM3, a cerebral cavernous malformation protein critical for…
3RQG 2.5 Å, Cerebral cavernous malformation 3 (CCM3) in complex with paxillin LD4
3RQF 2.7 Å, Cerebral cavernous malformation 3 (CCM3) in complex with paxillin LD2
3RQE 2.8 Å, Cerebral cavernous malformation 3 (CCM3) in complex with paxillin LD1
4TVQ 2.8 Å, CCM3 in complex with CCM2 LD-like motif
3L8J 3.05 Å, Crystal structure of CCM3, a cerebral cavernous malformation protein critical for…

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