N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) is a 223-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9BV86.
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The mean pLDDT of this model is 97.6 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 97% |
| 70 to 90 | Confident: backbone generally right | 3% |
| 50 to 70 | Low: treat with caution | 0% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation (PubMed:24090352). Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5CVD | X-ray | 1.3 Å | A/B=1-223 |
| 6WJ7 | X-ray | 1.42 Å | B=2-223 |
| 5E1D | X-ray | 1.45 Å | A/B=2-223 |
| 6DTN | X-ray | 1.48 Å | B=2-223 |
| 5CVE | X-ray | 1.5 Å | A/B=1-223 |
| 6KDQ | X-ray | 1.5 Å | A/B=1-223 |
| 6PVB | X-ray | 1.5 Å | B=2-223 |
| 5E1B | X-ray | 1.65 Å | A/B=2-223 |
| 6WH8 | X-ray | 1.73 Å | A/B=2-223 |
| 2EX4 | X-ray | 1.75 Å | A/B=2-223 |
| 5E1M | X-ray | 1.75 Å | A/B=2-223 |
| 5E2A | X-ray | 1.75 Å | A/B=2-223 |
| 6PVA | X-ray | 1.84 Å | B=2-223 |
| 5E2B | X-ray | 1.95 Å | A/B=2-223 |
| 5E1O | X-ray | 2.0 Å | A/B=2-223 |
| 7K3D | X-ray | 2.34 Å | A/B=2-223 |
| 7SS1 | X-ray | 2.4 Å | A/B=2-223 |
| 7U1M | X-ray | 3.17 Å | A/B=2-223 |
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