DET1- and DDB1-associated protein 1 (DDA1) is a 102-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9BW61.
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The mean pLDDT of this model is 66.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 50% |
| 50 to 70 | Low: treat with caution | 34% |
| Below 50 | Very low: often disordered regions | 16% |
What pLDDT means and how to read it
Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17452440, PubMed:28302793, PubMed:28437394, PubMed:31686031, PubMed:31819272). In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex (PubMed:31686031, PubMed:31819272)
Component of numerous DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which consist of a core of DDB1, cullin-4 (CUL4A or CUL4B), DDA1 and RBX1 (PubMed:28302793, PubMed:28437394, PubMed:31686031, PubMed:31693891, PubMed:31693911, PubMed:31819272). Component of the DCX(DCAF15) complex, also named CLR4(DCAF15) complex, composed of DCAF15, DDB1, cullin-4 (CUL4A or CUL4B), DDA1 and RBX1…
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9BZ0 | EM | 1.9 Å | e=1-102 |
| 8G46 | EM | 2.2 Å | E=1-102 |
| 6UD7 | X-ray | 2.3 Å | D=2-102 |
| 6UE5 | X-ray | 2.61 Å | D=2-102 |
| 8TL6 | EM | 2.63 Å | E=1-102 |
| 9LTJ | EM | 2.65 Å | F=1-102 |
| 9BJZ | EM | 2.83 Å | C=1-102 |
| 6PAI | X-ray | 2.9 Å | E=1-102 |
| 6Q0R | X-ray | 2.9 Å | E=1-102 |
| 6Q0V | X-ray | 2.9 Å | E=1-102 |
| 6Q0W | X-ray | 2.9 Å | E=1-102 |
| 9DHD | EM | 2.9 Å | C=1-102 |
| 9LTO | EM | 2.92 Å | D=1-102 |
| 9LTL | EM | 2.93 Å | F=1-102 |
| 9LTR | EM | 3.03 Å | I/P=1-102 |
| 9C5U | EM | 3.05 Å | C=1-102 |
| 6DSZ | X-ray | 3.09 Å | C/D=1-19 |
| 8ROY | EM | 3.1 Å | D=1-102 |
| 9LTW | EM | 3.25 Å | F=1-102 |
| 9LTZ | EM | 3.26 Å | F=1-102 |
Showing 20 of 29 experimental structures (best resolution first).
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