Brother of CDO (BOC) is a 1114-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9BWV1.
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The mean pLDDT of this model is 63.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 10% |
| 70 to 90 | Confident: backbone generally right | 43% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 38% |
What pLDDT means and how to read it
Together with CDON, forms a coreceptor required for sonic hedgehog (SHH) handoff to its patched receptor (PTCH1 or PTCH2), thereby allowing activation of the smoothened signaling pathway (By similarity). Binds to the dually lipid-modified Sonic hedgehog protein N-product (ShhN) downstream of SCUBE2 carrier and promotes its release to GAS1 (By similarity). ShhN is then directly transferred to patched receptor by GAS1 (By similarity). May also mediate cell-cell interactions between muscle precursor cells, promoting differentiation of myogenic cells (By similarity)
Heterodimer; heterodimerizes with CDON to form a functional complex (PubMed:11782431, PubMed:12634428). Component of a complex composed of BOC, CDON, NEO1, cadherins and CTNNB1 (By similarity). Interacts with DHH, IHH and SHH (PubMed:20519495). Interacts with CDH2 and CTNNB1 (PubMed:12634428). Interacts with CDH15 only during the early stages of myoblast differentiation (PubMed:12634428)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3N1M | X-ray | 1.69 Å | C=710-817 |
| 3N1G | X-ray | 1.9 Å | C/D=710-817 |
| 3N1P | X-ray | 2.7 Å | C=710-817 |
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