Serrate RNA effector molecule homolog (SRRT) is a 876-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9BXP5.
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The mean pLDDT of this model is 66.0 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 29% |
| 70 to 90 | Confident: backbone generally right | 23% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 43% |
What pLDDT means and how to read it
Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and…
Interacts with NCBP1 and DROSHA (By similarity). Interacts with CASP8AP2 and ERBB4. Interacts with LUZP4. Interacts with NCBP2/CBP20 and NCBP3 (PubMed:26382858). Interacts with MTREX (PubMed:30842217)
Nucleus, nucleoplasm, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5OO6 | X-ray | 2.8 Å | C/F/I/L/O/R/U/X=832-876 |
| 6F7J | X-ray | 3.22 Å | A=171-270, B=409-764 |
| 6F7S | X-ray | 3.37 Å | A/B=147-270, C/D=409-568, C/D=600-764 |
| 8PMP | EM | 3.43 Å | D=148-876 |
| 6F8D | X-ray | 3.48 Å | A/B=171-270, C/D=409-764 |
| 6F7P | X-ray | 3.7 Å | A/B=147-270, C/D=409-764 |
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