Dedicator of cytokinesis protein 9 (DOCK9) is a 2069-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9BZ29.
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The mean pLDDT of this model is 78.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 40% |
| 70 to 90 | Confident: backbone generally right | 39% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation
Homodimer (Probable). Interacts preferentially with nucleotide-depleted CDC42
Endomembrane system
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2WM9 | X-ray | 2.2 Å | A=1605-2069 |
| 2WMO | X-ray | 2.2 Å | A=1605-2069 |
| 2WMN | X-ray | 2.39 Å | A=1605-2069 |
| 1WG7 | NMR | A=165-301 |
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