E3 ubiquitin-protein ligase TRIM7 (TRIM7) is a 511-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9C029.
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The mean pLDDT of this model is 85.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 62% |
| 70 to 90 | Confident: backbone generally right | 26% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
E3 ubiquitin-protein ligase that have both tumor-promoting and tumor-suppressing activities and functions in several biological processes including innate immunity, regulation of ferroptosis as well as cell proliferation and migration (PubMed:25851810, PubMed:32853985, PubMed:34062120). Acts as an antiviral effector against multiple viruses by targeting specific viral proteins for ubiquitination and degradation including norovirus NTPase protein or SARS-CoV-2 NSP5 and NSP8 proteins (PubMed:34062120, PubMed:35982226). Mechanistically, recognizes the C-terminal glutamine-containing motif usually generated by viral proteases that process the polyproteins and trigger their ubiquitination and…
Forms homodimers (PubMed:35893676). Interacts with GNIP2 (PubMed:14984203, PubMed:25851810). Interacts with GYG1 (PubMed:11916970, PubMed:14984203, PubMed:33989636). Interacts with RNF187 (via C-terminus) (PubMed:25851810)
Nucleus, Cytoplasm, Golgi apparatus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7W0Q | X-ray | 1.1 Å | A=338-511 |
| 7X70 | X-ray | 1.25 Å | A=338-511 |
| 7X6Y | X-ray | 1.39 Å | A=338-511 |
| 7W0S | X-ray | 1.4 Å | B/C/E=338-511 |
| 7X6Z | X-ray | 1.43 Å | A=338-511 |
| 9HIN | X-ray | 1.55 Å | A=338-511 |
| 7W0T | X-ray | 1.57 Å | B/C/F=338-511 |
| 6UMA | X-ray | 1.6 Å | A/B=338-511 |
| 8R5B | X-ray | 1.6 Å | A/B=338-511 |
| 8R5C | X-ray | 1.6 Å | A=338-511 |
| 8A5L | X-ray | 1.62 Å | A=342-511 |
| 7OVX | X-ray | 1.7 Å | A=342-511 |
| 7Y3A | X-ray | 1.7 Å | A/B/C=338-511 |
| 7Y3C | X-ray | 1.71 Å | A=338-511 |
| 7Y3B | X-ray | 1.76 Å | A=338-511 |
| 6UMB | X-ray | 1.8 Å | A/B=338-511 |
| 8R5D | X-ray | 1.8 Å | A/B=338-511 |
| 7OW2 | X-ray | 2.17 Å | A/B/C/D=342-511 |
| 8A8X | X-ray | 2.37 Å | A/C=342-511 |
| 8A5M | X-ray | 2.92 Å | A/B=342-511 |
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