Tripartite motif-containing protein 2 (TRIM2) is a 744-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9C040.
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The mean pLDDT of this model is 84.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 54% |
| 70 to 90 | Confident: backbone generally right | 32% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity (PubMed:24068738)
Forms homooligomers (PubMed:36481767). Interacts with TRIM3; this interaction reduces TRIM2 activity (PubMed:36481767). Interacts with myosin V; myosin V may not be a substrate for ubiquitination (By similarity). Interacts with NEFL (By similarity). Interacts with phosphorylated BCL2L11. Interacts with SIRPA (By similarity)
Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7QRV | X-ray | 1.45 Å | A/B/C/D=466-744 |
| 7B2R | X-ray | 1.6 Å | A/B=466-740 |
| 7B96 | X-ray | 1.8 Å | A/B=469-744 |
| 8A38 | X-ray | 2.2 Å | A/B/C=8-100 |
| 8AMS | X-ray | 2.4 Å | C/D=8-157 |
| 7ZJ3 | X-ray | 2.53 Å | A/D/G/J=2-95 |
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