Matrix remodeling-associated protein 8 (Mxra8) is a 442-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9DBV4.
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The mean pLDDT of this model is 74.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 44% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 24% |
What pLDDT means and how to read it
Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3 (PubMed:18366072, PubMed:22492581, PubMed:29702220). Mediates heterophilic cell-cell interactions in vitro (PubMed:18366072). Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (PubMed:22492581). Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (PubMed:29702220). Stimulates formation of primary cilia in chondrocytes (PubMed:29702220). Enhances expression of genes involved in the hedgehog signaling pathway…
Homodimer in cis (PubMed:18366072). Does not appear to form trans-homodimers (PubMed:18366072). Interacts with ITGB3; the interaction inhibits ITGAV:ITGB3 heterodimer formation (PubMed:22492581)
Cell membrane, Cell junction, tight junction, Cytoplasm, Cell projection, cilium membrane, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6NK3 | X-ray | 2.2 Å | A/B=23-296 |
| 6JO7 | X-ray | 2.4 Å | A/B=23-291 |
| 8SQN | EM | 3.89 Å | A=32-65, A=197-294 |
| 8EWF | EM | 3.92 Å | E=32-65, E=197-294 |
| 6NK6 | EM | 4.06 Å | M/N/O/P=32-299 |
| 6NK7 | EM | 4.99 Å | N=32-292 |
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