Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (CTDSP1) is a 261-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9GZU7.
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The mean pLDDT of this model is 81.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 68% |
| 70 to 90 | Confident: backbone generally right | 2% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 24% |
What pLDDT means and how to read it
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells
Monomer (By similarity). Interacts with GTF2F1. Interacts with REST
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2GHT | X-ray | 1.8 Å | A/B=77-256 |
| 2GHQ | X-ray | 2.05 Å | A/B=77-256 |
| 1TA0 | X-ray | 2.1 Å | A=77-261 |
| 4YH1 | X-ray | 2.2 Å | A/B=77-255 |
| 1T9Z | X-ray | 2.3 Å | A=77-261 |
| 3L0Y | X-ray | 2.3 Å | A/B=77-256 |
| 3L0B | X-ray | 2.35 Å | A/B=77-256 |
| 3PGL | X-ray | 2.35 Å | A/B=77-256 |
| 4YGY | X-ray | 2.36 Å | A/B=77-261 |
| 3L0C | X-ray | 2.45 Å | A/B=77-256 |
| 6DU3 | X-ray | 2.58 Å | A/B=77-256 |
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