1TA0: PDB entry 1TA0

Three-dimensional structure of a RNA-polymerase II binding protein with associated ligand. Determined by X-ray diffraction at 2.1 Å resolution. Released 31 Aug 2004.

Method: X-ray diffraction
Resolution: 2.1 Å
Organism: Homo sapiens
Chains: 1
Atoms: 1,637
Mol. weight: 22.93 kDa
Ligands: BEF, CIT, MG
Released: 31 Aug 2004

Explore 1TA0 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1TA0 contains 13 α-helices and 11 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 13 helices, 11 β-strands

Element	Residues	Length	Sheet
α-helix	82-84	3
α-helix	85-87	3
α-helix	91	1
β-strand	92-95	4	1
β-strand	98	1	2
β-strand	102-105	4	2
β-strand	114-120	7	2
β-strand	123-131	9	2
α-helix	132	1
α-helix	135-145	11
β-strand	147-151	5	1
α-helix	156-166	11
β-strand	172-176	5	1
α-helix	178-180	3
β-strand	182-184	3	3
β-strand	187-189	3	3
α-helix	192-194	3
α-helix	199-201	3
β-strand	202-205	4	1
α-helix	209-212	4
α-helix	216-218	3
β-strand	219	1	1
α-helix	233-244	12
α-helix	250-254	5

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1	A	protein	197	Homo sapiens	Q9GZU7 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1TA0_1 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (chains A)
MQYLLPEAKAQDSDKICVVIDLDETLVHSSFKPVNNADFIIPVEIDGVVHQVYVLKRPHV
DEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRESCVFHRGNYVKDLSRL
GRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSDTELHDLLPFFEQLSRVDDVYSVLR
QPRPGSAAALEHHHHHH

Ligands and cofactors

ID	Name	Formula	Copies
BEF	Beryllium trifluoride ion	Be F3	1
CIT	Citric acid	C6 H8 O7	1
MG	Magnesium ion	Mg	1

Primary citation

Structure and Mechanism of RNA Polymerase II CTD Phosphatases. Kamenski, T., Heilmeier, S., Meinhart, T. et al. Mol Cell (2004) 15:399-407. DOI 10.1016/j.molcel.2004.06.035 · PubMed

Other PDB entries of the same protein (UniProt Q9GZU7 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2GHT 1.8 Å, CTD-specific phosphatase Scp1 in complex with peptide from C-terminal domain of RNA…
2GHQ 2.05 Å, CTD-specific phosphatase Scp1 in complex with peptide C-terminal domain of RNA…
4YH1 2.2 Å, Structure of Human Scp1 bound to cis-proline peptidomimetic CTD phospho-Ser5 peptide
1T9Z 2.3 Å, Three-dimensional structure of a RNA-polymerase II binding protein.
3L0Y 2.3 Å, Crystal structure OF SCP1 phosphatase D98A mutant
3L0B 2.35 Å, Crystal structure of SCP1 phosphatase D206A mutant phosphoryl-intermediate
3PGL 2.35 Å, Crystal structure of human small C-terminal domain phosphatase 1 (Scp1) bound to…
4YGY 2.36 Å, Crystal Structure of Human Scp1 bound to trans-proline peptidomimetic CTD phospho-Ser5…
3L0C 2.45 Å, Crystal structure of SCP1 phosphatase D206A mutant with trapped inorganic phosphate
6DU3 2.58 Å, Structure of Scp1 D96N bound to REST-pS861/4 peptide

Browse structure collections

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