Bromodomain-containing protein 9 (BRD9) is a 597-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9H8M2.
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The mean pLDDT of this model is 63.0 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 20% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 17% |
| Below 50 | Very low: often disordered regions | 42% |
What pLDDT means and how to read it
Plays a role in chromatin remodeling and regulation of transcription (PubMed:22464331, PubMed:26365797). Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797). Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). Also orchestrates the RAD51-RAD54 complex formation and thereby plays a role in homologous recombination (HR) (PubMed:32457312)
Binds acetylated histones H3 and H4 (PubMed:22464331, PubMed:26365797). Binds butyrylated histone H4 (PubMed:26365797). Component of the multiprotein chromatin-remodeling subcomplex SWI/SNF called GBAF, which includes at least BICRA or BICRAL (mutually exclusive), BRD9, SS18, the core BAF subunits, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, SMARCC1/BAF155, and SMARCD1/BAF60A…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6BQA | X-ray | 1.03 Å | A=138-239 |
| 5I40 | X-ray | 1.04 Å | A=138-239 |
| 5I7X | X-ray | 1.18 Å | A=138-238 |
| 6Y7K | X-ray | 1.2 Å | A=134-243 |
| 4UIT | X-ray | 1.3 Å | A=134-238 |
| 6V1B | X-ray | 1.35 Å | A/B=134-243 |
| 5JI8 | X-ray | 1.42 Å | A=137-239 |
| 4YY6 | X-ray | 1.45 Å | A=134-239 |
| 5I7Y | X-ray | 1.45 Å | A=138-238 |
| 4YY4 | X-ray | 1.47 Å | A=134-239 |
| 4YYI | X-ray | 1.5 Å | A/B/D/E=134-239 |
| 6V0X | X-ray | 1.5 Å | A=134-243 |
| 6YQW | X-ray | 1.5 Å | A=134-238 |
| 8AHC | X-ray | 1.5 Å | A/B=134-243 |
| 4YYD | X-ray | 1.52 Å | A=134-239 |
| 5EU1 | X-ray | 1.6 Å | A/B=134-243 |
| 5IGM | X-ray | 1.6 Å | A/B=134-243 |
| 6Y7I | X-ray | 1.6 Å | A/B=134-243 |
| 6Y7J | X-ray | 1.6 Å | A/B=134-243 |
| 4UIU | X-ray | 1.64 Å | A=134-238 |
Showing 20 of 55 experimental structures (best resolution first).
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