Aly/REF export factor 2 (Alyref2) is a 218-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9JJW6.
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The mean pLDDT of this model is 67.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 11% |
| 70 to 90 | Confident: backbone generally right | 38% |
| 50 to 70 | Low: treat with caution | 26% |
| Below 50 | Very low: often disordered regions | 25% |
What pLDDT means and how to read it
Export adapter involved in spliced and unspliced mRNA nuclear export. Binds mRNA which is transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway); enhances NXF1-NXT1 RNA-binding activity
Interacts (via N-terminus and RRM domain) with DDX39B and the NXF1-NXT1 heterodimer. Interacts with HHV-1 ICP27 and HVS ORF57 proteins
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8SRR | EM | 3.22 Å | C=1-155 |
| 2F3J | NMR | A=1-155 | |
| 2KT5 | NMR | A=53-155 | |
| 2YKA | NMR | A=53-155 |
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