Polycomb protein Su(z)12 (Su(z)12) is a 900-residue protein from Drosophila melanogaster. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9NJG9.
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The mean pLDDT of this model is 65.5 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 27% |
| 70 to 90 | Confident: backbone generally right | 25% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 40% |
What pLDDT means and how to read it
Polycomb group (PcG) protein. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. Component of the Esc/E(z) complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required
Component of the polycomb repressive complex 2 (PRC2, also known as the Esc/E(Z) complex), composed of Caf1-55, esc, E(z), Su(z)12, and possibly pho (PubMed:12408863, PubMed:12408864). PRC2 associates with the accessory components Jarid2 and jing to form the PRC2 Jarid2-jing variant (PRC2.2) (PubMed:22354997). PRC2 may also associate with Pcl and HDAC1/Rpd3 during early embryogenesis…
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2YB8 | X-ray | 2.3 Å | A=79-91 |
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