N-lysine methyltransferase KMT5A (KMT5A) is a 393-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9NQR1.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 64.5 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 41% |
| 70 to 90 | Confident: backbone generally right | 4% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 47% |
What pLDDT means and how to read it
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins (PubMed:12086618, PubMed:12121615, PubMed:15964846, PubMed:17707234, PubMed:27338793). Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1) (PubMed:12086618, PubMed:12121615, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:15964846, PubMed:16517599, PubMed:27338793). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression (PubMed:12086618, PubMed:12121615, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:15964846, PubMed:16517599). Mainly functions in euchromatin regions, thereby playing a central role in the silencing…
Interacts with L3MBTL1
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3F9X | X-ray | 1.25 Å | A/B/C/D=232-393 |
| 5TEG | X-ray | 1.3 Å | A/B=234-393 |
| 1ZKK | X-ray | 1.45 Å | A/B/C/D=231-393 |
| 2BQZ | X-ray | 1.5 Å | A/E=233-393 |
| 3F9Y | X-ray | 1.5 Å | A/B=232-393 |
| 3F9W | X-ray | 1.6 Å | A/B/C/D=232-393 |
| 3F9Z | X-ray | 1.6 Å | A/B/C/D=232-393 |
| 5W1Y | X-ray | 1.7 Å | A/B=232-393 |
| 5TH7 | X-ray | 1.95 Å | A/B=234-380 |
| 4IJ8 | X-ray | 2.0 Å | A/B=232-393 |
| 5V2N | X-ray | 2.0 Å | A=231-393 |
| 9CR7 | X-ray | 2.05 Å | A/B=232-380 |
| 5T5G | X-ray | 2.1 Å | A=234-380 |
| 6BOZ | X-ray | 2.4 Å | A/B=232-393 |
| 7D20 | EM | 3.0 Å | K=45-393 |
| 7D1Z | EM | 3.15 Å | K=45-393 |
| 7XPX | EM | 3.2 Å | K=194-393 |
| 5HQ2 | X-ray | 4.5 Å | M=194-393 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.