Potassium voltage-gated channel subfamily KQT member 5 (KCNQ5) is a 932-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9NR82.
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The mean pLDDT of this model is 56.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 20% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 56% |
What pLDDT means and how to read it
Pore-forming subunit of the voltage-gated potassium (Kv) channel broadly expressed in brain and involved in the regulation of neuronal excitability (PubMed:10787416, PubMed:10816588, PubMed:11159685, PubMed:28669405). Associates with KCNQ3/Kv7.3 pore-forming subunit to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons (PubMed:10816588, PubMed:11159685). Contributes, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which…
Homotetramer; forms a functional homotetrameric channel resulting in the expression of a small M-current (PubMed:10816588, PubMed:29429937). Heterotetramer with KCNQ3; forms heterotetrameric M-channel responsible for the native M-current (PubMed:10787416, PubMed:10816588, PubMed:11159685). Heterotetramer with KCNQ1; forms a functional voltage-gated potassium channel (PubMed:24855057). Interacts…
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9J38 | EM | 2.4 Å | A/B/C/D=89-698 |
| 6B8Q | X-ray | 2.6 Å | A/C/E/G=361-394, A/C/E/G=512-545 |
| 9LJ5 | EM | 2.9 Å | A/B/D/G=90-698 |
| 9LIZ | EM | 3.1 Å | A/B/D/G=90-698 |
| 9LJ1 | EM | 3.2 Å | A/B/D/G=90-698 |
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