6B8Q: Mg2+/CaM:Kv7.5 (KCNQ5) AB domain complex

Crystal Structure of the Mg2+/CaM:Kv7.5 (KCNQ5) AB domain complex. Determined by X-ray diffraction at 2.6 Å resolution. Released 14 Mar 2018.

Method: X-ray diffraction
Resolution: 2.6 Å
Organism: Homo sapiens
Chains: 8
Atoms: 6,648
Mol. weight: 103.15 kDa
Ligands: MG
Released: 14 Mar 2018

Explore 6B8Q in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6B8Q contains 46 α-helices and 16 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	367-382	16
α-helix	516-538	23

Chain B: 8 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	6-19	14
β-strand	26-27	2	1
α-helix	29-37	9
α-helix	45-53	9
β-strand	63-64	2	1
α-helix	65-74	10
α-helix	79-90	12
β-strand	99-101	3	2
α-helix	102-109	8
α-helix	118-128	11
β-strand	135-137	3	2
α-helix	138-146	9

Chain C: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	368-382	15
α-helix	391-393	3
α-helix	518-538	21

Chain D: 9 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	9-19	11
β-strand	26-27	2	3
α-helix	29-38	10
α-helix	45-53	9
β-strand	63-64	2	3
α-helix	65-74	10
α-helix	79-91	13
β-strand	100-101	2	4
α-helix	102-111	10
α-helix	115-117	3
α-helix	118-128	11
β-strand	135-136	2	4
α-helix	138-145	8

Chain E: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	369-382	14
α-helix	391-393	3
α-helix	518-538	21

Chain F: 9 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	6-19	14
β-strand	27	1	5
α-helix	29-38	10
α-helix	45-53	9
β-strand	63	1	5
α-helix	66-74	9
α-helix	79-91	13
β-strand	99-101	3	6
α-helix	102-111	10
α-helix	115-117	3
α-helix	118-128	11
β-strand	135-137	3	6
α-helix	139-144	6

Chain G: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	362-382	21
α-helix	516-538	23

Chain H: 10 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	3-5	3
α-helix	6-19	14
β-strand	26-27	2	7
α-helix	29-38	10
α-helix	45-55	11
β-strand	63-64	2	7
α-helix	65-74	10
α-helix	79-90	12
β-strand	99-101	3	8
α-helix	102-111	10
α-helix	115-117	3
α-helix	118-128	11
β-strand	135-137	3	8
α-helix	138-146	9

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Potassium voltage-gated channel subfamily KQT member 5	A, C, E, G	protein	75	Homo sapiens	Q9NR82 (AlphaFold model)
Calmodulin-1	B, D, F, H	protein	149	Homo sapiens	P0DP23 (AlphaFold model)

Sequence of entity 1 (A, C, E, G), FASTA

>6B8Q_1 Potassium voltage-gated channel subfamily KQT member 5 (chains A, C, E, G)
GHMASKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWKKLEDLTPPLKTVIRAIRIMKF
HVAKRKFKETLRPYD

Sequence of entity 2 (B, D, F, H), FASTA

>6B8Q_2 Calmodulin-1 (chains B, D, F, H)
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	15

Primary citation

A Calmodulin C-Lobe Ca. Chang, A., Abderemane-Ali, F., Hura, G.L. et al. Neuron (2018) 97:836-852.e6. DOI 10.1016/j.neuron.2018.01.035 · PubMed

Other PDB entries of the same protein (UniProt Q9NR82 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9J38 2.4 Å, human KCNQ5-CaM in apo state
9LJ5 2.9 Å, Human KCNQ5-CaM-PIP2-HN37 complex in an open conformation.
9LIZ 3.1 Å, Human KCNQ5-CaM in complex with PIP2
9LJ1 3.2 Å, Human KCNQ5-CaM-PIP2-HN37 complex in a closed conformation.

Browse structure collections

About this viewer

MolViewer shows 6B8Q directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.