Hypoxia-inducible factor 1-alpha inhibitor (HIF1AN) is a 349-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9NWT6.
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The mean pLDDT of this model is 91.4 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 85% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation.…
Homodimer; homodimerization is essential for catalytic activity. Interacts with VHL and HIF1A. Part of a complex with VHL, HIF1A and HDAC1 or HDAC2 or HDAC3. Interacts with NFKB1 and NFKBIA. Interacts with NOTCH1, NOTCH2 and NOTCH3 but not with NOTCH4. Interacts with APBA3; binding inhibits HIF1AN binding to HIF1A. Interacts with TNKS2. Interacts with PPP1R12A. Interacts with ASB4 (By…
Nucleus, Cytoplasm, Cytoplasm, perinuclear region
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7A1Q | X-ray | 1.75 Å | A=1-349 |
| 7A1P | X-ray | 1.76 Å | A=1-349 |
| 6H9J | X-ray | 1.83 Å | A=12-349 |
| 6HC8 | X-ray | 1.9 Å | A=1-349 |
| 6HKP | X-ray | 1.9 Å | A=1-349 |
| 7A1J | X-ray | 1.9 Å | A=1-349 |
| 6HL6 | X-ray | 1.97 Å | A=1-349 |
| 6HA6 | X-ray | 1.98 Å | A=1-349 |
| 6HL5 | X-ray | 1.98 Å | A=1-349 |
| 7A1K | X-ray | 1.99 Å | A=1-349 |
| 7A1N | X-ray | 2.01 Å | A=1-349 |
| 7A1S | X-ray | 2.01 Å | A=1-349 |
| 8K73 | X-ray | 2.02 Å | A=1-349 |
| 8II0 | X-ray | 2.04 Å | A=1-349 |
| 9JTX | X-ray | 2.08 Å | A=1-349 |
| 3D8C | X-ray | 2.1 Å | A=11-349 |
| 4Z1V | X-ray | 2.1 Å | A=1-349 |
| 5JWP | X-ray | 2.1 Å | A=1-349 |
| 2W0X | X-ray | 2.12 Å | A=1-349 |
| 1H2K | X-ray | 2.15 Å | A=1-349 |
Showing 20 of 64 experimental structures (best resolution first).
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