NAD-dependent protein deacylase sirtuin-5, mitochondrial (SIRT5) is a 310-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9NXA8.
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The mean pLDDT of this model is 89.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 84% |
| 70 to 90 | Confident: backbone generally right | 3% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693, PubMed:29180469). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Activates SHMT2 by mediating its desuccinylation (PubMed:29180469). Modulates…
Interacts with CPS1 (By similarity). Interacts with PCCA (PubMed:23438705). Monomer (PubMed:17355872). Homodimer (PubMed:17355872). Forms homodimers upon suramin binding (PubMed:17355872)
Mitochondrion matrix, Mitochondrion intermembrane space, Cytoplasm, cytosol, Nucleus, Cytoplasm, Mitochondrion
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6EQS | X-ray | 1.32 Å | A/B/C/D=34-302 |
| 6LJK | X-ray | 1.39 Å | A=34-302 |
| 8Z54 | X-ray | 1.45 Å | A=36-302 |
| 3RIY | X-ray | 1.55 Å | A/B=34-302 |
| 5BWL | X-ray | 1.55 Å | A=33-302 |
| 7X3P | X-ray | 1.56 Å | A=34-310 |
| 4F56 | X-ray | 1.7 Å | A/B=34-302 |
| 6ACO | X-ray | 1.71 Å | A=34-302 |
| 6LJM | X-ray | 1.78 Å | A=34-302 |
| 6LJN | X-ray | 1.8 Å | A=34-302 |
| 8Z56 | X-ray | 1.81 Å | A=36-302 |
| 8Z55 | X-ray | 1.83 Å | A=36-302 |
| 2B4Y | X-ray | 1.9 Å | A/B/C/D=34-302 |
| 6ACL | X-ray | 1.92 Å | A=36-302 |
| 4G1C | X-ray | 1.94 Å | A/B=36-302 |
| 8Z57 | X-ray | 1.96 Å | A=36-302 |
| 6ACE | X-ray | 1.98 Å | A=36-302 |
| 3RIG | X-ray | 2.0 Å | A/B=34-302 |
| 4F4U | X-ray | 2.0 Å | A/B=34-302 |
| 2NYR | X-ray | 2.06 Å | A/B=34-302 |
Showing 20 of 26 experimental structures (best resolution first).
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