Q9NXV2: BTB/POZ domain-containing protein KCTD5 (KCTD5)

BTB/POZ domain-containing protein KCTD5 (KCTD5) is a 234-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9NXV2.

Gene: KCTD5
Organism: Homo sapiens
Length: 234 residues
Mean pLDDT: 77.6
Model: AF-Q9NXV2-F1 v6
Model created: 1 Aug 2025
PDB structures: 9

Explore in 3D Color by confidence AlphaFold DB UniProt

Model confidence (pLDDT)

The mean pLDDT of this model is 77.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.

pLDDT band	Meaning	Share of residues
Above 90	Very high: backbone and side chains are usually accurate	53%
70 to 90	Confident: backbone generally right	13%
50 to 70	Low: treat with caution	12%
Below 50	Very low: often disordered regions	22%

What pLDDT means and how to read it

Function

Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex (PubMed:18573101). Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4 (PubMed:19361449)

Subunit structure

Homopentamer (PubMed:19361449). Interacts (via C-terminus) with GRASP55/GORASP2 (PubMed:19361449). Interacts with CUL3 and with ubiquitinated proteins (PubMed:18573101). Interacts with CRY1 (By similarity)

Subcellular location

Cytoplasm, cytosol, Cytoplasm, Nucleus

Experimental structures in the PDB

Compare the prediction with experimentally determined structures of the same protein:

PDB ID	Method	Resolution	Chains and residues
3DRZ	X-ray	1.9 Å	A/B/C/D/E=40-145
8U7Z	EM	2.97 Å	K1/K2/K3/K4/K5=1-234
3DRX	X-ray	3.11 Å	A/B/C/D/E=34-234
3DRY	X-ray	3.3 Å	A/B/C/D/E=34-234
8U80	EM	3.6 Å	K1/K2/K3/K4/K5=1-234
8U81	EM	3.82 Å	K1/K2/K3/K4/K5=1-233
8U82	EM	3.84 Å	K1/K2/K3/K4/K5=1-234
8U84	EM	3.88 Å	K1/K2/K3/K4/K5=1-234
8U83	EM	3.98 Å	K1/K2/K3/K4/K5=1-234

More AlphaFold highlights

About this viewer

MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.