Ewing's tumor-associated antigen 1 (ETAA1) is a 926-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9NY74.
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The mean pLDDT of this model is 49.3 (very low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 4% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 16% |
| Below 50 | Very low: often disordered regions | 70% |
What pLDDT means and how to read it
Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity (PubMed:27601467, PubMed:27723717, PubMed:27723720). Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 (PubMed:27723717, PubMed:27723720, PubMed:30139873). Probably only regulates a subset of ATR targets (PubMed:27723717, PubMed:27723720)
Interacts (via RBM1 motif) with RPA1 (PubMed:27601467, PubMed:27723717, PubMed:27723720). Interacts (via RBM2 motif) with RPA2 (PubMed:27601467, PubMed:27723717, PubMed:27723720). Interacts (via the ATR-activation domain motif) with ATR (PubMed:27723717, PubMed:27723720)
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8JZV | X-ray | 1.5 Å | B=599-622 |
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