Programmed cell death 1 ligand 1 (CD274) is a 290-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9NZQ7.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 88.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 71% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813410, PubMed:28813417, PubMed:31399419). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443, PubMed:28813410, PubMed:28813417, PubMed:36727298). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077). Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis…
Interacts with PDCD1 (PubMed:11015443, PubMed:18287011, PubMed:26602187). Interacts (via transmembrane domain) with CMTM4 and CMTM6 (PubMed:28813410, PubMed:28813417). Interacts with (phosphorylated) STAT3; promoting nuclear translocation (PubMed:32929201). Interacts with CD80 (PubMed:36727298)
Cell membrane, Early endosome membrane, Recycling endosome membrane, Nucleus, Endomembrane system, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5O45 | X-ray | 0.99 Å | A=17-134 |
| 8ALX | X-ray | 1.1 Å | A=18-134 |
| 6NP9 | X-ray | 1.27 Å | A=18-134 |
| 9I0U | X-ray | 1.46 Å | A/B=18-134 |
| 6YCR | X-ray | 1.54 Å | A=18-134 |
| 8AOK | X-ray | 1.6 Å | A=18-134 |
| 7CZD | X-ray | 1.64 Å | B/D=19-134 |
| 5JDS | X-ray | 1.7 Å | A=18-132 |
| 5N2F | X-ray | 1.7 Å | A/B=18-134 |
| 9QSM | X-ray | 1.75 Å | A/B/C/D/E/F=18-134 |
| 8ZNL | X-ray | 1.77 Å | B/D/F/H=19-132 |
| 5C3T | X-ray | 1.8 Å | A=18-134 |
| 7OUN | X-ray | 1.9 Å | A=17-134 |
| 6NNV | X-ray | 1.92 Å | A/B/C/D=18-134 |
| 4Z18 | X-ray | 1.95 Å | A/B=19-239 |
| 8XR5 | X-ray | 1.95 Å | A/B=19-134 |
| 6PV9 | X-ray | 2.0 Å | A=19-239 |
| 7C88 | X-ray | 2.0 Å | C/M=1-136 |
| 7SJQ | X-ray | 2.0 Å | A=18-134 |
| 5NIU | X-ray | 2.01 Å | A/B/C/D=18-134 |
Showing 20 of 74 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.