Polymerase basic protein 2 (PB2) is a 770-residue protein from Influenza B virus. This is its AlphaFold structure prediction, created 1 Jan 2024. UniProt accession: Q9QLL6.
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The mean pLDDT of this model is 85.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 43% |
| 70 to 90 | Confident: backbone generally right | 49% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds a wide range of cap structures of target pre-RNAs which are subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex
Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PB1 (via C-terminus). Interacts with nucleoprotein NP (via N-terminus). Interacts with host ANP32A (via C-terminus) and ANP32B; these interactions promote viral RNA synthesis (PubMed:33045004)
Virion, Host nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5EF9 | X-ray | 1.7 Å | A=320-485 |
| 5EFA | X-ray | 1.9 Å | A=320-485 |
| 5EFC | X-ray | 1.9 Å | A=320-485 |
| 6XQA | X-ray | 2.16 Å | C/F=550-558 |
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