Short transient receptor potential channel 4 (Trpc4) is a 974-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9QUQ5.
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The mean pLDDT of this model is 74.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 44% |
| 70 to 90 | Confident: backbone generally right | 27% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 25% |
What pLDDT means and how to read it
Forms a receptor-activated non-selective calcium permeant cation channel (By similarity). Acts as a cell-cell contact-dependent endothelial calcium entry channel (By similarity). Forms a homomeric ion channel or a heteromeric ion channel with TRPC1; the heteromeric ion channel has reduced calcium permeability compared to the homomeric channel (By similarity). Also permeable to monovalent ions including sodium, lithium and cesium ions (By similarity)
Homotetramer (PubMed:19070363). Heterotetramer with TRPC1 and/or TRPC5 (By similarity). Forms a heteromeric ion channel with TRPC1, with a 1:3 TRPC1:TRPC4 stoichiometry (By similarity). Interacts with TRPC4AP (PubMed:20458742). Isoform alpha but not isoform beta interacts with ITPR1, ITPR2 and ITPR3 (By similarity). Interacts with NHERF1 (By similarity). Interacts with MX1 and RNF24 (By…
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7CQP | X-ray | 1.9 Å | C=785-812 |
| 5Z96 | EM | 3.28 Å | A/B/C/D=1-755 |
| 6JZO | EM | 3.28 Å | A/B/C/D=1-755 |
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